DDT - a novel domain in different transcription and chromosome remodeling factors

被引：52
作者：
Doerks, T
Copley, R
Bork, P
机构：
[1] European Mol Biol Lab, D-69012 Heidelberg, Germany
[2] Max Delbrueck Ctr, D-13092 Berlin, Germany
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 03期
关键词：
D O I：
10.1016/S0968-0004(00)01769-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three a helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
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收藏
页码：145 / 146
页数：2
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