In vitro susceptibility of Coxiella burnetii to trovafloxacin in comparison with susceptibilities to pefloxacin, ciprofloxacin, ofloxacin, doxycycline, and clarithromycin

The antibiotic susceptibilities of eight Greek isolates of Coxiella burnetii to trovafloxacin were determined by the shell vial assay. MICs of trovafloxacin and ofloxacin ranged from 1 to 2 mu g/ml, those of pefloxacin ranged from 1 to 4 mu g/ml, those of ciprofloxacin ranged from 4 to 8 mu g/ml, those of doxycycline ranged from 1 to 2 mu g/ml, and those of clarithromycin ranged from 2 to 4 mu g/ml. Trovafloxacin exhibited no activity against C. burnetii at 4 mu g/ml.