Gd-Si Oxide Nanoparticles as Contrast Agents in Magnetic Resonance Imaging

被引：11
作者：
Cabrera-Garcia, Alejandro [1 ]
Vidal-Moya, Alejandro [1 ]
Bernabeu, Angela [2 ]
Pacheco-Torres, Jesus [3 ]
Checa-Chavarria, Elisa [4 ,5 ]
Fernandez, Eduardo [4 ,5 ]
Botella, Pablo [1 ]
机构：
[1] Univ Politecn Valencia, CSIC, Inst Tecnol Quim, Ave Naranjos S-N, E-46022 Valencia, Spain
[2] Hosp Univ Alicante, Unit Magnet Resonance Imaging, INSCANNER SL, Alicante, Spain
[3] Inst Neurociencias CSIC UMH, Unit Funct Magnet Resonance Imaging, Alicante, Spain
[4] Univ Miguel Hernandez, Inst Bioengn, Elche, Spain
[5] Ctr Network Biomed Res CIBER BBN, Barcelona, Spain
来源：
NANOMATERIALS | 2016年 / 6卷 / 06期
关键词：
Prussian Blue analogues; Gd-Si nanoparticles; magnetic resonance imaging; contrast agent; MESOPOROUS SILICA NANOPARTICLES; METAL-ORGANIC-FRAMEWORKS; RELAXIVITY; CANCER; MR; NANOSPHERES; THERANOSTICS; NANOPROBES; THERAPY;
D O I：
10.3390/nano6060109
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis, characterization and application as contrast agents in magnetic resonance imaging of a novel type of magnetic nanoparticle based on Gd-Si oxide, which presents high Gd3+ atom density. For this purpose, we have used a Prussian Blue analogue as the sacrificial template by reacting with soluble silicate, obtaining particles with nanorod morphology and of small size (75 nm). These nanoparticles present good biocompatibility and higher longitudinal and transversal relaxivity values than commercial Gd3+ solutions, which significantly improves the sensitivity of in vivo magnetic resonance images.
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页数：15
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