Iridium-catalyzed direct C-H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

被引：20

作者：

Wang, Lianhui

Yang, Zi

Yang, Mengqi

Zhang, Rongyi

Kuai, Changsheng

Cui, Xiuling ^{[1
]}

机构：

[1] Huaqiao Univ, Key Lab Xiamen Marine & Gene Drugs, Inst Mol Med, Engn Res Ctr Mol Med,Minist Educ, Xiamen 361021, Fujian, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 39期

关键词：

N-PIVALOYLINDOLES; NITROGEN-SOURCE; ACYL AZIDES; ARENES; AMINATION; ACTIVATION; MILD; FUNCTIONALIZATION; LIGANDS; INDOLES;

D O I：

10.1039/c7ob01899a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Ir(III)-catalyzed regioselective C-H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the mono-amidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.

引用

页码：8302 / 8307

页数：6

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