Iridium-catalyzed direct C-H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes

被引：20
作者：
Wang, Lianhui
Yang, Zi
Yang, Mengqi
Zhang, Rongyi
Kuai, Changsheng
Cui, Xiuling [1 ]
机构：
[1] Huaqiao Univ, Key Lab Xiamen Marine & Gene Drugs, Inst Mol Med, Engn Res Ctr Mol Med,Minist Educ, Xiamen 361021, Fujian, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 39期
关键词：
N-PIVALOYLINDOLES; NITROGEN-SOURCE; ACYL AZIDES; ARENES; AMINATION; ACTIVATION; MILD; FUNCTIONALIZATION; LIGANDS; INDOLES;
D O I：
10.1039/c7ob01899a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An Ir(III)-catalyzed regioselective C-H amidation of anilines with sulfonyl azides is described. The developed protocol has good compatibility with diverse functional groups, efficiently providing the mono-amidated products with good to excellent yields under mild reaction conditions. Furthermore, the 2-pyrimidyl and sulfonyl moieties in the amidated products can readily be removed, offering the synthetically useful 1,2-diaminobenzene scaffold.
引用
收藏
页码：8302 / 8307
页数：6
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