New Cytotoxic Pregnane-type Steroid from the Stem Bark of Aglaia elliptica (Meliaceae)

被引：13

作者：

Farabi, Kindi ^{[1
]}

Harneti, Desi ^{[1
]}

Nurlelasari ^{[1
]}

Maharani, Rani ^{[1
]}

Hidayat, Ace Tatang ^{[1
,2
]}

Awang, Khalijah ^{[3
]}

Supratman, Unang ^{[1
,2
]}

Shiono, Yoshihito ^{[4
]}

机构：

[1] Univ Padjadjaran, Fac Math & Nat Sci, Dept Chem, Jatinangor 45363, Sumedang, Indonesia

[2] Univ Padjadjaran, Cent Lab, Jatinangor 45363, Sumdeang, Indonesia

[3] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 59100, Malaysia

[4] Yamagata Univ, Fac Agr, Dept Food Life & Environm Sci, Tsuruoka, Yamagata 9978555, Japan

来源：

RECORDS OF NATURAL PRODUCTS | 2018年 / 12卷 / 02期

关键词：

Pregnane-type steroid; Aglaia elliptica; cytotoxic activity; Meliaceae; DAMMARANE TRITERPENES; EXIMIA MELIACEAE; CONSTITUENTS; LEAVES; ODORATA; DITERPENOIDS; FOVEOLATA;

D O I：

10.25135/rnp.21.17.07.118

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new pregnane-type steroid, 2 alpha-hydroxy-3 alpha-methoxy-5 alpha-pregnane (1), together with three known dammarane-type triterpenoid, 3 beta-acetyl-20S, 24S-epoxy-25-hydroxydammarane (2), 20S, 24S-epoxy-3 alpha, 25dihydroxydammarane (3), and eichlerianic acid (4) have been isolated from the stem bark of Aglaia elliptica. The structures were determined by spectroscopic methods including the 2D-NMR techniques. Compound 1-4 showed moderate cytotoxic activity against P-388 murine leukemia cells.

引用

收藏

页码：121 / 127

页数：7

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