Anticholinesterase activity of standardized extract of Illicium verum Hook. f. fruits

被引：42

作者：

Bhadra, Santanu ^{[1
]}

Mukherjee, Pulok K. ^{[1
]}

Kumar, N. Satheesh ^{[1
]}

Bandyopadhyay, A. ^{[2
]}

机构：

[1] Jadavpur Univ, Dept Pharmaceut Technol, Sch Nat Prod Studies, Kolkata 700032, India

[2] Indian Inst Chem Biol, Kolkata 700032, India

来源：

FITOTERAPIA | 2011年 / 82卷 / 03期

关键词：

Acetylcholinesterase; Butyrylcholinesterase; Anethole; Illicium verum; Alzheimer's disease; ACETYLCHOLINESTERASE INHIBITORY-ACTIVITY; ESSENTIAL OIL; COMPONENTS; PLANTS;

D O I：

10.1016/j.fitote.2010.11.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Illicium verum is a well known spice in traditional Indian system for its therapeutic potential. The present study was aimed to evaluate the acetylcholinesterase (AChE) and butyrylcholinesterase inhibitory (BChE) activity of standardized extracts of I. verum and its oil. Present study confirmed that anethole contributed to the anticholinesterase activity of I. verum, with more specificity towards AChE. IC50 for AChE and BChE inhibitory activity of anethole was 39.89 +/- 0.32 mu g/mL and 75.35 +/- 1.47 mu g/ml, whereas for the oil, 36.00 +/- 0.44 mu g/mL and 70.65 +/- 0.96 mu g/mL respectively. Therefore I. verum can be a good lead as anti-cholinesterase agent from natural resources. (c) 2010 Elsevier B.V. All rights reserved.

引用

页码：342 / 346

页数：5

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