Ultrasonic-Mediated Green Synthesis of Novel S-Arylated-Pyridopyrimidines and Antimicrobial Evaluation against Escherichia coli and Staphylococcus aureus

被引：3
|
作者：
Riadi, Yassine [1 ]
Afzal, Obaid [1 ]
Al-Tamimi, Abdul-Malek S. [1 ]
Ali, Abuzer [2 ]
Ali, Amena [3 ]
机构：
[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Al Kharj 11942, Saudi Arabia
[2] Taif Univ, Coll Pharm, Dept Pharmacognosy, At Taif, Saudi Arabia
[3] Taif Univ, Coll Pharm, Dept Pharmaceut Chem, At Taif, Saudi Arabia
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2022年 / 42卷 / 09期
关键词：
Antibacterial activity; S-arylated-pyrido[2; 3-d]pyrimidines; ultrasonic irradiation; water; green; DIHYDROFOLATE-REDUCTASE; PNEUMOCYSTIS-CARINII; TOXOPLASMA-GONDII; INHIBITORS; DERIVATIVES; FUNCTIONALIZATION; DISCOVERY; EFFICIENT; ANALOGS; MIXTURE;
D O I：
10.1080/10406638.2021.1984953
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile, eco-friendly and effective ultrasonic strategy to synthesize S-arylated-pyridopyrimidines is described starting from 4-thiol or 4-halogenopyridopyrimidines through a reaction involving a green procedure under ultrasonic irradiation and in presence of water as green solvent. The resulted derivatives were assessed for the antibacterial activity against different bacteria strains.
引用
收藏
页码：6546 / 6553
页数：8
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