Efficient C2 functionalisation of 2H-2-imidazolines

被引：28
|
作者：
Bon, Robin S. [1 ]
Sprenkels, Nanda E. [1 ]
Koningstein, Manoe M. [1 ]
Schmitz, Rob F. [1 ]
de Kanter, Frans J. J. [1 ]
Doemling, Alexander [2 ]
Groen, Marinus B. [1 ]
Orru, Romano V. A. [1 ]
机构：
[1] Vrije Univ Amsterdam, Dept Chem, NL-1081 HV Amsterdam, Netherlands
[2] Univ Pittsburgh, Pittsburgh, PA 15261 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 01期
关键词：
D O I：
10.1039/b713065a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).
引用
收藏
页码：130 / 137
页数：8
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