Cross-presentation, dendrttic cells, tolerance and immunity

被引：707
作者：
Heath, WR
Carbone, FR
机构：
[1] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3050, Australia
来源：
ANNUAL REVIEW OF IMMUNOLOGY | 2001年 / 19卷
关键词：
cross-priming; antigen presentation; cytotoxic T lymphocytes; CD8; T cells;
D O I：
10.1146/annurev.immunol.19.1.47
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
引用
收藏
页码：47 / 64
页数：18
相关论文
共 93 条
[1]   CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells [J].
Adler, AJ ;
Marsh, DW ;
Yochum, GS ;
Guzzo, JL ;
Nigam, A ;
Nelson, WG ;
Pardoll, DM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1555-1564
[2]   Dendritic cells acquire antigen from apoptotic cells and induce class I restricted CTLs [J].
Albert, ML ;
Sauter, B ;
Bhardwaj, N .
NATURE, 1998, 392 (6671) :86-89
[3]   Immature dendritic cells phagocytose apoptotic cells via αvβ5 and CD36, and cross-present antigens to cytotoxic T lymphocytes [J].
Albert, ML ;
Pearce, SFA ;
Francisco, LM ;
Sauter, B ;
Roy, P ;
Silverstein, RL ;
Bhardwaj, N .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (07) :1359-1368
[4]  
ANSORGE S, 1984, BIOMED BIOCHIM ACTA, V43, P1213
[5]   CROSS-PRIMING OF MINOR HISTOCOMPATIBILITY ANTIGEN-SPECIFIC CYTOTOXIC T-CELLS UPON IMMUNIZATION WITH THE HEAT-SHOCK PROTEIN GP96 [J].
ARNOLD, D ;
FAATH, S ;
RAMMENSEE, HG ;
SCHILD, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) :885-889
[6]   Dendritic cells and the control of immunity [J].
Banchereau, J ;
Steinman, RM .
NATURE, 1998, 392 (6673) :245-252
[7]   SELECTIVE KILLING OF HEPATITIS-B ENVELOPE ANTIGEN-SPECIFIC B-CELLS BY CLASS-I-RESTRICTED, EXOGENOUS ANTIGEN-SPECIFIC LYMPHOCYTES-T [J].
BARNABA, V ;
FRANCO, A ;
ALBERTI, A ;
BENVENUTO, R ;
BALSANO, F .
NATURE, 1990, 345 (6272) :258-260
[8]  
Bellone M, 1997, J IMMUNOL, V159, P5391
[9]   Expression and localization of the annexins II, V, and VI in myocardium from patients with end-stage heart failure [J].
Benevolensky, D ;
Belikova, Y ;
Mohammadzadeh, R ;
Trouvé, P ;
Marotte, F ;
Russo-Marie, F ;
Samuel, JL ;
Charlemagne, D .
LABORATORY INVESTIGATION, 2000, 80 (02) :123-133
[10]   Help for cytotoxic-T-cell responses is mediated by CD40 signalling [J].
Bennett, SRM ;
Carbone, FR ;
Karamalis, F ;
Flavell, RA ;
Miller, JFAP ;
Heath, WR .
NATURE, 1998, 393 (6684) :478-480
12345678910