Inhaled nitric oxide use in preterm infants in California neonatal intensive care units

被引：18

作者：

Handley, S. C. ^{[1
]}

Steinhorn, R. H. ^{[2
]}

Hopper, A. O. ^{[3
]}

Govindaswami, B. ^{[4
]}

Bhatt, D. R. ^{[5
]}

Van Meurs, K. P. ^{[6
]}

Ariagno, R. L. ^{[6
,7
,8
]}

Gould, J. B. ^{[6
,9
]}

Lee, H. C. ^{[6
,9
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[2] Univ Calif Davis, Dept Pediat, Davis, CA 95616 USA

[3] Loma Linda Univ, Dept Pediat, Loma Linda, CA 92350 USA

[4] Santa Clara Valley Med Ctr, Dept Pediat, San Jose, CA 95128 USA

[5] Kaiser Permanente, Dept Pediat, Fontana, CA USA

[6] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[7] Oak Ridge Inst Res & Educ ORISE, Oak Ridge, TN USA

[8] US FDA, Silver Spring, MD USA

[9] CPQCC, Stanford, CA USA

来源：

JOURNAL OF PERINATOLOGY | 2016年 / 36卷 / 08期

关键词：

RESPIRATORY-FAILURE;

D O I：

10.1038/jp.2016.49

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use. STUDY DESIGN: This was a retrospective cohort study of infants, 22 to 33+ 6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation. RESULTS: Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+ 6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+ 6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%). CONCLUSION: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.

引用

页码：635 / 639

页数：5

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