Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities

被引：31

作者：

Du, Guang-Jian

Dai, Qing ^{[2
]}

Williams, Stainley

Wang, Chong-Zhi

Yuan, Chun-Su ^{[1
]}

机构：

[1] Univ Chicago, Dept Anesthesia & Crit Care, Tang Ctr Herbal Med Res, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

来源：

ANTI-CANCER DRUGS | 2011年 / 22卷 / 01期

关键词：

apoptosis; cell cycle; colon cancer; protopanaxadiol derivatives; semisynthesis; NATURAL-PRODUCTS; AMERICAN GINSENG; POTENTIAL ROLE; CONSTITUENTS; DRUGS; CELLS;

D O I：

10.1097/CAD.0b013e32833fde29

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Protopanaxadiol (PPD), an aglycon of ginseng saponins, has shown anticancer activity in earlier studies. Here, we have reported the semisynthesis of nine PPD derivatives with acetyl substitutions. Subsequently, the antiproliferative effects of these nine analogs on different human cancer cell lines have been investigated. Compounds 1, 3, and 5 showed more significant and more potent antiproliferative activity compared with PPD and other derivatives. A flow cytometric assay indicated that compounds 1, 3, and 5 arrested cell cycle progression in the G1 phase and significantly induced apoptosis of cancer cells. Anti-Cancer Drugs 22: 35-45 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：35 / 45

页数：11

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