Preliminary focus on the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles

被引：74

作者：

Russo, T. ^{[1
]}

Gloria, A. ^{[1
]}

De Santis, R. ^{[1
]}

D'Amora, U. ^{[1
]}

Balato, G. ^{[2
]}

Vollaro, A. ^{[3
]}

Oliviero, O. ^{[2
]}

Improta, G. ^{[2
]}

Triassi, M. ^{[2
]}

Ambrosio, L. ^{[1
]}

机构：

[1] CNR, Inst Polymers Composites & Biomat, Naples, Italy

[2] Univ Naples Federico II, Sch Med, Dept Publ Hlth, Naples, Italy

[3] Univ Naples Federico II, Sch Med, Dept Mol Med & Med Biotechnol, Naples, Italy

来源：

BIOACTIVE MATERIALS | 2017年 / 2卷 / 03期

关键词：

Nanocomposite; Bone cement; Gold nanoparticles; Antibacterial activity; Mechanical properties; SILVER NANOPARTICLES; KNEE ARTHROPLASTY; ADHESIVES; COMPOSITE;

D O I：

10.1016/j.bioactmat.2017.05.002

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In total knee arthroplasty (TKA) and total hip replacement (THR) the restoration of the normal joint function represents a fundamental feature. A prosthetic joint must be able to provide motions and to transmit functional loads. As reported in the literature, the stress distribution may be altered in bones after the implantation of a total joint prosthesis. Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component. Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections. Furthermore, nanoparticles with antimicrobial activity have been widely analysed. Accordingly, the current research was focused on a preliminary analysis of the mechanical and antibacterial activity of a PMMA-based bone cement loaded with gold nanoparticles. The obtained results demonstrated that nanocomposite cements with a specific concentration of gold nanoparticles improved the punching performance and antibacterial activity. However, critical aspects were found in the optimization of the nanocomposite bone cement. (C) 2017 The Authors. Production and hosting by Elsevier B.V.

引用

页码：156 / 161

页数：6