Palladium-Catalyzed Cross-Coupling of Aryl Chlorides and Tosylates with Hydrazine

被引：140
|
作者：
Lundgren, Rylan J. [1 ]
Stradiotto, Mark [1 ]
机构：
[1] Dalhousie Univ, Dept Chem, Halifax, NS B3H 4J3, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 46期
基金：
加拿大自然科学与工程研究理事会;
关键词：
amination; cross-coupling; homogeneous catalysis; hydrazine; P; N ligands; N-ARYLATION; C-N; EFFICIENT SYNTHESIS; INTRAMOLECULAR AMINATION; REGIOSELECTIVE SYNTHESIS; HALIDES; 1-ARYL-1H-INDAZOLES; AMMONIA; N; N-DIALKYLHYDRAZINES; CONVERSION;
D O I：
10.1002/anie.201003764
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrazine is not a problem anymore: The title transformation is the first reaction to yield aryl hydrazines through the cross-coupling of aryl chlorides and tosylates with hydrazine. An appropriately designed palladium catalyst allows this reaction to proceed rapidly under mild conditions, and with excellent chemoselectivity (see scheme; Ad=adamantyl, Ts=4-toluenesulfonyl). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8686 / 8690
页数：5
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