New insight into RNase P RNA structure from comparative analysis of the archaeal RNA

被引:84
作者
Harris, JK
Haas, ES
Williams, D
Frank, DN
Brown, JW
机构
[1] N Carolina State Univ, Dept Microbiol, Raleigh, NC 27695 USA
[2] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
关键词
Archaea; archaebacteria; ribonuclease P; ribozyme; rnpB;
D O I
10.1017/S1355838201001777
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A detailed comparative analysis of archaeal RNase P RNA structure and a comparison of the resulting structural information with that of the bacterial RNA reveals that the archaeal RNase P RNAs are strikingly similar to those of Bacteria. The differences between the secondary structure models of archaeal and bacterial RNase P RNA have largely disappeared, and even variation in the sequence and structure of the RNAs are similar in extent and type. The structure of the cruciform (P7-11) has been reevaluated on the basis of a total of 321 bacterial and archaeal sequences, leading to a model for the structure of this region of the RNA that includes an extension to P11 that consistently organizes the cruciform and adjacent highly-conserved sequences.
引用
收藏
页码:220 / 232
页数:13
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