Updated Field Synopsis and Systematic Meta-Analyses of Genetic Association Studies in Cutaneous Melanoma: The MelGene Database

被引：30

作者：

Antonopoulou, Kyriaki ^{[1
]}

Stefanaki, Irene ^{[1
]}

Lill, Christina M. ^{[2
,3
]}

Chatzinasiou, Foteini ^{[1
]}

Kypreou, Katerina P. ^{[1
]}

Karagianni, Fani ^{[1
]}

Athanasiadis, Emmanouil ^{[4
]}

Spyrou, George M. ^{[4
]}

Ioannidis, John P. A. ^{[5
]}

Bertram, Lars ^{[2
,6
]}

Evangelou, Evangelos ^{[7
,8
]}

Stratigos, Alexander J. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Dermatol, Andreas Sygros Hosp, Athens 16121, Greece

[2] Max Planck Inst Mol Genet, Dept Vertebrate Genom, Neuropsychiat Genet Grp, D-14195 Berlin, Germany

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Neurol, Focus Program Translat Neurosci, D-55122 Mainz, Germany

[4] Acad Athens, Biomed Res Fdn, Ctr Syst Biol, Athens, Greece

[5] Stanford Univ, Dept Med, Sch Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA

[6] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Med, London, England

[7] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Clin & Mol Epidemiol Unit, GR-45110 Ioannina, Greece

[8] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2015年 / 135卷 / 04期

关键词：

GENOME-WIDE ASSOCIATION; MITF GERMLINE MUTATION; CANCER SUSCEPTIBILITY; IDENTIFIES; VARIANTS; POLYMORPHISMS; PREDISPOSES; CONTRIBUTE; RISK;

D O I：

10.1038/jid.2014.491

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We updated a field synopsis of genetic associations of cutaneous melanoma (CM) by systematically retrieving and combining data from all studies in the field published as of August 31, 2013. Data were available from 197 studies, which included 83,343 CM cases and 187,809 controls and reported on 1,126 polymorphisms in 289 different genes. Random-effects meta-analyses of 81 eligible polymorphisms evaluated in >4 data sets confirmed 20 single-nucleotide polymorphisms across 10 loci (TYR, AFG3L1P, CDK10, MYH7B, SLC45A2, MTAP, ATM, CLPTM1L, FTO, and CASP8) that have previously been published with genome-wide significant evidence for association (P<5 x 10(-8)) with CM risk, with certain variants possibly functioning as proxies of already tagged genes. Four other loci (MITF, CCND1, MX2, and PLA2G6) were also significantly associated with 5 x 10-8 <P<1 x 10(-3). In supplementary meta-analyses derived from genome-wide association studies, one additional locus located 11 kb upstream of ARNT (chromosome 1q21) showed genome-wide statistical significance with CM. Our approach serves as a useful model in analyzing and integrating the reported germline alterations involved in CM.

引用

页码：1074 / 1079

页数：6

共 36 条

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Akulevich, Natallia M. ;

Saenko, Vladimir A. ;

Rogounovitch, Tatiana I. ;

Drozd, Valentina M. ;

Lushnikov, Eugeny F. ;

Ivanov, Victor K. ;

Mitsutake, Norisato ;

Kominami, Ryo ;

Yamashita, Shunichi .

[2] An integrated map of genetic variation from 1,092 human genomes [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Schmidt, Jeanette P. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Dinh, Huyen ;

Kovar, Christie ;

Lee, Sandra ;

Lewis, Lora ;

Muzny, Donna ;

Reid, Jeff ;

Wang, Min ;

Wang, Jun ;

Fang, Xiaodong ;

Guo, Xiaosen ;

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Jin, Xin ;

Li, Guoqing ;

Li, Jingxiang ;

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Amos, Christopher I. ;

Wang, Li-E ;

Lee, Jeffrey E. ;

Gershenwald, Jeffrey E. ;

Chen, Wei V. ;

Fang, Shenying ;

Kosoy, Roman ;

Zhang, Mingfeng ;

Qureshi, Abrar A. ;

Vattathil, Selina ;

Schacherer, Christopher W. ;

Gardner, Julie M. ;

Wang, Yuling ;

Bishop, D. Tim ;

Barrett, Jennifer H. ;

MacGregor, Stuart ;

Hayward, Nicholas K. ;

Martin, Nicholas G. ;

Duffy, David L. ;

Mann, Graham J. ;

Cust, Anne ;

Hopper, John ;

Brown, Kevin M. ;

Grimm, Elizabeth A. ;

Xu, Yaji ;

Han, Younghun ;

Jing, Kaiyan ;

McHugh, Caitlin ;

Laurie, Cathy C. ;

Doheny, Kim F. ;

Pugh, Elizabeth W. ;

Seldin, Michael F. ;

Han, Jiali ;

Wei, Qingyi .

HUMAN MOLECULAR GENETICS, 2011, 20 (24) :5012-5023

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Athanasiadis, Emmanouil I. ;

Antonopoulou, Kyriaki ;

Chatzinasiou, Foteini ;

Lill, Christina M. ;

Bourdakou, Marilena M. ;

Sakellariou, Argiris ;

Kypreou, Katerina ;

Stefanaki, Irene ;

Evangelou, Evangelos ;

Ioannidis, John P. A. ;

Bertram, Lars ;

Stratigos, Alexander J. ;

Spyrou, George M. .

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2014,

[5] Genome-wide association study identifies three new melanoma susceptibility loci [J].

Barrett, Jennifer H. ;

Iles, Mark M. ;

Harland, Mark ;

Taylor, John C. ;

Aitken, Joanne F. ;

Andresen, Per Arne ;

Akslen, Lars A. ;

Armstrong, Bruce K. ;

Avril, Marie-Francoise ;

Azizi, Esther ;

Bakker, Bert ;

Bergman, Wilma ;

Bianchi-Scarra, Giovanna ;

Bressac-de Paillerets, Brigitte ;

Calista, Donato ;

Cannon-Albright, Lisa A. ;

Corda, Eve ;

Cust, Anne E. ;

Debniak, Tadeusz ;

Duffy, David ;

Dunning, Alison M. ;

Easton, Douglas F. ;

Friedman, Eitan ;

Galan, Pilar ;

Ghiorzo, Paola ;

Giles, Graham G. ;

Hansson, Johan ;

Hocevar, Marko ;

Hoeiom, Veronica ;

Hopper, John L. ;

Ingvar, Christian ;

Janssen, Bart ;

Jenkins, Mark A. ;

Joensson, Goeran ;

Kefford, Richard F. ;

Landi, Giorgio ;

Landi, Maria Teresa ;

Lang, Julie ;

Lubinski, Jan ;

Mackie, Rona ;

Malvehy, Josep ;

Martin, Nicholas G. ;

Molven, Anders ;

Montgomery, Grant W. ;

van Nieuwpoort, Frans A. ;

Novakovic, Srdjan ;

Olsson, Hakan ;

Pastorino, Lorenza ;

Puig, Susana ;

Puig-Butille, Joan Anton .

NATURE GENETICS, 2011, 43 (11) :1108-U98

[6]

Belbasis L, 2014, AM J EPIDEM IN PRESS

[7] A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma [J].

Bertolotto, Corine ;

Lesueur, Fabienne ;

Giuliano, Sandy ;

Strub, Thomas ;

de Lichy, Mahaut ;

Bille, Karine ;

Dessen, Philippe ;

d'Hayer, Benoit ;

Mohamdi, Hamida ;

Remenieras, Audrey ;

Maubec, Eve ;

de la Fouchardiere, Arnaud ;

Molinie, Vincent ;

Vabres, Pierre ;

Dalle, Stephane ;

Poulalhon, Nicolas ;

Martin-Denavit, Tanguy ;

Thomas, Luc ;

Andry-Benzaquen, Pascale ;

Dupin, Nicolas ;

Boitier, Francoise ;

Rossi, Annick ;

Perrot, Jean-Luc ;

Labeille, Bruno ;

Robert, Caroline ;

Escudier, Bernard ;

Caron, Olivier ;

Brugieres, Laurence ;

Saule, Simon ;

Gardie, Betty ;

Gad, Sophie ;

Richard, Stephane ;

Couturier, Jerome ;

Teh, Bin Tean ;

Ghiorzo, Paola ;

Pastorino, Lorenza ;

Puig, Susana ;

Badenas, Celia ;

Olsson, Hakan ;

Ingvar, Christian ;

Rouleau, Etienne ;

Lidereau, Rosette ;

Bahadoran, Philippe ;

Vielh, Philippe ;

Corda, Eve ;

Blanche, Helene ;

Zelenika, Diana ;

Galan, Pilar ;

Chaudru, Valerie ;

Lenoir, Gilbert M. .

NATURE, 2011, 480 (7375) :94-U259

[8] Genome-wide association study identifies three loci associated with melanoma risk [J].

Bishop, D. Timothy ;

Demenais, Florence ;

Iles, Mark M. ;

Harland, Mark ;

Taylor, John C. ;

Corda, Eve ;

Randerson-Moor, Juliette ;

Aitken, Joanne F. ;

Avril, Marie-Francoise ;

Azizi, Esther ;

Bakker, Bert ;

Bianchi-Scarra, Giovanna ;

Bressac-de Paillerets, Brigitte ;

Calista, Donato ;

Cannon-Albright, Lisa A. ;

Chin-A-Woeng, Thomas ;

Debniak, Tadeusz ;

Galore-Haskel, Gilli ;

Ghiorzo, Paola ;

Gut, Ivo ;

Hansson, Johan ;

Hocevar, Marko ;

Hoiom, Veronica ;

Hopper, John L. ;

Ingvar, Christian ;

Kanetsky, Peter A. ;

Kefford, Richard F. ;

Landi, Maria Teresa ;

Lang, Julie ;

Lubinski, Jan ;

Mackie, Rona ;

Malvehy, Josep ;

Mann, Graham J. ;

Martin, Nicholas G. ;

Montgomery, Grant W. ;

van Nieuwpoort, Frans A. ;

Novakovic, Srdjan ;

Olsson, Hakan ;

Puig, Susana ;

Weiss, Marjan ;

van Workum, Wilbert ;

Zelenika, Diana ;

Brown, Kevin M. ;

Goldstein, Alisa M. ;

Gillanders, Elizabeth M. ;

Boland, Anne ;

Galan, Pilar ;

Elder, David E. ;

Gruis, Nelleke A. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2009, 41 (08) :920-U85

[9] Common sequence variants on 20q11.22 confer melanoma susceptibility [J].

Brown, Kevin M. ;

MacGregor, Stuart ;

Montgomery, Grant W. ;

Craig, David W. ;

Zhao, Zhen Zhen ;

Iyadurai, Kelly ;

Henders, Anjali K. ;

Homer, Nils ;

Campbell, Megan J. ;

Stark, Mitchell ;

Thomas, Shane ;

Schmid, Helen ;

Holland, Elizabeth A. ;

Gillanders, Elizabeth M. ;

Duffy, David L. ;

Maskiell, Judith A. ;

Jetann, Jodie ;

Ferguson, Megan ;

Stephan, Dietrich A. ;

Cust, Anne E. ;

Whiteman, David ;

Green, Adele ;

Olsson, Hakan ;

Puig, Susana ;

Ghiorzo, Paola ;

Hansson, Johan ;

Demenais, Florence ;

Goldstein, Alisa M. ;

Gruis, Nelleke A. ;

Elder, David E. ;

Bishop, Julia Newton ;

Kefford, Richard F. ;

Giles, Graham G. ;

Armstrong, Bruce K. ;

Aitken, Joanne F. ;

Hopper, John L. ;

Martin, Nicholas G. ;

Trent, Jeffrey M. ;

Mann, Graham J. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2008, 40 (07) :838-840

[10] Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma [J].

Chatzinasiou, Foteini ;

Lill, Christina M. ;

Kypreou, Katerina ;

Stefanaki, Irene ;

Nicolaou, Vasiliki ;

Spyrou, George ;

Evangelou, Evangelos ;

Roehr, Johannes T. ;

Kodela, Elizabeth ;

Katsambas, Andreas ;

Tsao, Hensin ;

Ioannidis, John P. A. ;

Bertram, Lars ;

Stratigos, Alexander J. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (16) :1227-1235

← 1 2 3 4 →

共 36 条

[1] Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma [J].

Akulevich, Natallia M. ;

Saenko, Vladimir A. ;

Rogounovitch, Tatiana I. ;

Drozd, Valentina M. ;

Lushnikov, Eugeny F. ;

Ivanov, Victor K. ;

Mitsutake, Norisato ;

Kominami, Ryo ;

Yamashita, Shunichi .

[2] An integrated map of genetic variation from 1,092 human genomes [J].

Altshuler, David M. ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Donnelly, Peter ;

Eichler, Evan E. ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Green, Eric D. ;

Hurles, Matthew E. ;

Knoppers, Bartha M. ;

Korbel, Jan O. ;

Lander, Eric S. ;

Lee, Charles ;

Lehrach, Hans ;

Mardis, Elaine R. ;

Marth, Gabor T. ;

McVean, Gil A. ;

Nickerson, Deborah A. ;

Schmidt, Jeanette P. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Dinh, Huyen ;

Kovar, Christie ;

Lee, Sandra ;

Lewis, Lora ;

Muzny, Donna ;

Reid, Jeff ;

Wang, Min ;

Wang, Jun ;

Fang, Xiaodong ;

Guo, Xiaosen ;

Jian, Min ;

Jiang, Hui ;

Jin, Xin ;

Li, Guoqing ;

Li, Jingxiang ;

Li, Yingrui ;

Li, Zhuo ;

Liu, Xiao ;

Lu, Yao ;

Ma, Xuedi ;

Su, Zhe ;

Tai, Shuaishuai ;

Tang, Meifang .

NATURE, 2012, 491 (7422) :56-65

[3] Genome-wide association study identifies novel loci predisposing to cutaneous melanoma [J].

Amos, Christopher I. ;

Wang, Li-E ;

Lee, Jeffrey E. ;

Gershenwald, Jeffrey E. ;

Chen, Wei V. ;

Fang, Shenying ;

Kosoy, Roman ;

Zhang, Mingfeng ;

Qureshi, Abrar A. ;

Vattathil, Selina ;

Schacherer, Christopher W. ;

Gardner, Julie M. ;

Wang, Yuling ;

Bishop, D. Tim ;

Barrett, Jennifer H. ;

MacGregor, Stuart ;

Hayward, Nicholas K. ;

Martin, Nicholas G. ;

Duffy, David L. ;

Mann, Graham J. ;

Cust, Anne ;

Hopper, John ;

Brown, Kevin M. ;

Grimm, Elizabeth A. ;

Xu, Yaji ;

Han, Younghun ;

Jing, Kaiyan ;

McHugh, Caitlin ;

Laurie, Cathy C. ;

Doheny, Kim F. ;

Pugh, Elizabeth W. ;

Seldin, Michael F. ;

Han, Jiali ;

Wei, Qingyi .

HUMAN MOLECULAR GENETICS, 2011, 20 (24) :5012-5023

[4] A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools [J].

Athanasiadis, Emmanouil I. ;

Antonopoulou, Kyriaki ;

Chatzinasiou, Foteini ;

Lill, Christina M. ;

Bourdakou, Marilena M. ;

Sakellariou, Argiris ;

Kypreou, Katerina ;

Stefanaki, Irene ;

Evangelou, Evangelos ;

Ioannidis, John P. A. ;

Bertram, Lars ;

Stratigos, Alexander J. ;

Spyrou, George M. .

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2014,

[5] Genome-wide association study identifies three new melanoma susceptibility loci [J].

Barrett, Jennifer H. ;

Iles, Mark M. ;

Harland, Mark ;

Taylor, John C. ;

Aitken, Joanne F. ;

Andresen, Per Arne ;

Akslen, Lars A. ;

Armstrong, Bruce K. ;

Avril, Marie-Francoise ;

Azizi, Esther ;

Bakker, Bert ;

Bergman, Wilma ;

Bianchi-Scarra, Giovanna ;

Bressac-de Paillerets, Brigitte ;

Calista, Donato ;

Cannon-Albright, Lisa A. ;

Corda, Eve ;

Cust, Anne E. ;

Debniak, Tadeusz ;

Duffy, David ;

Dunning, Alison M. ;

Easton, Douglas F. ;

Friedman, Eitan ;

Galan, Pilar ;

Ghiorzo, Paola ;

Giles, Graham G. ;

Hansson, Johan ;

Hocevar, Marko ;

Hoeiom, Veronica ;

Hopper, John L. ;

Ingvar, Christian ;

Janssen, Bart ;

Jenkins, Mark A. ;

Joensson, Goeran ;

Kefford, Richard F. ;

Landi, Giorgio ;

Landi, Maria Teresa ;

Lang, Julie ;

Lubinski, Jan ;

Mackie, Rona ;

Malvehy, Josep ;

Martin, Nicholas G. ;

Molven, Anders ;

Montgomery, Grant W. ;

van Nieuwpoort, Frans A. ;

Novakovic, Srdjan ;

Olsson, Hakan ;

Pastorino, Lorenza ;

Puig, Susana ;

Puig-Butille, Joan Anton .

NATURE GENETICS, 2011, 43 (11) :1108-U98

[6]

Belbasis L, 2014, AM J EPIDEM IN PRESS

[7] A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma [J].

Bertolotto, Corine ;

Lesueur, Fabienne ;

Giuliano, Sandy ;

Strub, Thomas ;

de Lichy, Mahaut ;

Bille, Karine ;

Dessen, Philippe ;

d'Hayer, Benoit ;

Mohamdi, Hamida ;

Remenieras, Audrey ;

Maubec, Eve ;

de la Fouchardiere, Arnaud ;

Molinie, Vincent ;

Vabres, Pierre ;

Dalle, Stephane ;

Poulalhon, Nicolas ;

Martin-Denavit, Tanguy ;

Thomas, Luc ;

Andry-Benzaquen, Pascale ;

Dupin, Nicolas ;

Boitier, Francoise ;

Rossi, Annick ;

Perrot, Jean-Luc ;

Labeille, Bruno ;

Robert, Caroline ;

Escudier, Bernard ;

Caron, Olivier ;

Brugieres, Laurence ;

Saule, Simon ;

Gardie, Betty ;

Gad, Sophie ;

Richard, Stephane ;

Couturier, Jerome ;

Teh, Bin Tean ;

Ghiorzo, Paola ;

Pastorino, Lorenza ;

Puig, Susana ;

Badenas, Celia ;

Olsson, Hakan ;

Ingvar, Christian ;

Rouleau, Etienne ;

Lidereau, Rosette ;

Bahadoran, Philippe ;

Vielh, Philippe ;

Corda, Eve ;

Blanche, Helene ;

Zelenika, Diana ;

Galan, Pilar ;

Chaudru, Valerie ;

Lenoir, Gilbert M. .

NATURE, 2011, 480 (7375) :94-U259

[8] Genome-wide association study identifies three loci associated with melanoma risk [J].

Bishop, D. Timothy ;

Demenais, Florence ;

Iles, Mark M. ;

Harland, Mark ;

Taylor, John C. ;

Corda, Eve ;

Randerson-Moor, Juliette ;

Aitken, Joanne F. ;

Avril, Marie-Francoise ;

Azizi, Esther ;

Bakker, Bert ;

Bianchi-Scarra, Giovanna ;

Bressac-de Paillerets, Brigitte ;

Calista, Donato ;

Cannon-Albright, Lisa A. ;

Chin-A-Woeng, Thomas ;

Debniak, Tadeusz ;

Galore-Haskel, Gilli ;

Ghiorzo, Paola ;

Gut, Ivo ;

Hansson, Johan ;

Hocevar, Marko ;

Hoiom, Veronica ;

Hopper, John L. ;

Ingvar, Christian ;

Kanetsky, Peter A. ;

Kefford, Richard F. ;

Landi, Maria Teresa ;

Lang, Julie ;

Lubinski, Jan ;

Mackie, Rona ;

Malvehy, Josep ;

Mann, Graham J. ;

Martin, Nicholas G. ;

Montgomery, Grant W. ;

van Nieuwpoort, Frans A. ;

Novakovic, Srdjan ;

Olsson, Hakan ;

Puig, Susana ;

Weiss, Marjan ;

van Workum, Wilbert ;

Zelenika, Diana ;

Brown, Kevin M. ;

Goldstein, Alisa M. ;

Gillanders, Elizabeth M. ;

Boland, Anne ;

Galan, Pilar ;

Elder, David E. ;

Gruis, Nelleke A. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2009, 41 (08) :920-U85

[9] Common sequence variants on 20q11.22 confer melanoma susceptibility [J].

Brown, Kevin M. ;

MacGregor, Stuart ;

Montgomery, Grant W. ;

Craig, David W. ;

Zhao, Zhen Zhen ;

Iyadurai, Kelly ;

Henders, Anjali K. ;

Homer, Nils ;

Campbell, Megan J. ;

Stark, Mitchell ;

Thomas, Shane ;

Schmid, Helen ;

Holland, Elizabeth A. ;

Gillanders, Elizabeth M. ;

Duffy, David L. ;

Maskiell, Judith A. ;

Jetann, Jodie ;

Ferguson, Megan ;

Stephan, Dietrich A. ;

Cust, Anne E. ;

Whiteman, David ;

Green, Adele ;

Olsson, Hakan ;

Puig, Susana ;

Ghiorzo, Paola ;

Hansson, Johan ;

Demenais, Florence ;

Goldstein, Alisa M. ;

Gruis, Nelleke A. ;

Elder, David E. ;

Bishop, Julia Newton ;

Kefford, Richard F. ;

Giles, Graham G. ;

Armstrong, Bruce K. ;

Aitken, Joanne F. ;

Hopper, John L. ;

Martin, Nicholas G. ;

Trent, Jeffrey M. ;

Mann, Graham J. ;

Hayward, Nicholas K. .

NATURE GENETICS, 2008, 40 (07) :838-840

[10] Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma [J].

Chatzinasiou, Foteini ;

Lill, Christina M. ;

Kypreou, Katerina ;

Stefanaki, Irene ;

Nicolaou, Vasiliki ;

Spyrou, George ;

Evangelou, Evangelos ;

Roehr, Johannes T. ;

Kodela, Elizabeth ;

Katsambas, Andreas ;

Tsao, Hensin ;

Ioannidis, John P. A. ;

Bertram, Lars ;

Stratigos, Alexander J. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (16) :1227-1235

← 1 2 3 4 →