Combined effect of cisplatin and alpha-tocopherol on mice bearing Dalton's lymphoma

被引：0
|
作者：
Sarna, S
Kumar, A
Bhola, RK
机构：
[1] Department of Zoology, Gauhati University, Guwahati 781 014, India
来源：
CURRENT SCIENCE | 1996年 / 70卷 / 11期
关键词：
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inhibitory effect of cisplatin and alpha-tocopherol on the growth of murine Dalton's lymphoma was studied in vivo. Subtherapeutical dose (3 mg/kg) of cisplatin was combined with different concentrations of alpha-tocopherol in order to increase the therapeutical benefit of this antitumour compound. This combination therapy not only increased the survival time of tumour-bearing mice but also resulted in tumour-free survivors. Such a treatment of Dalton's lymphoma is safer compared to cisplatin alone at higher doses due to its dose-related nephrotoxicity.
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页码：1022 / 1025
页数：4
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