A Multi-Component Sensor System for Detection of Amphiphilic Compounds

被引：55

作者：

Xu, Ming ^{[1
]}

Kelley, Steven P. ^{[1
]}

Glass, Timothy E. ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, 601 S Coll Ave, Columbia, MO 65211 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 39期

基金：

美国国家科学基金会;

关键词：

amphiphilic compounds; boronic acid; cucurbit[8]uril; glycolipids; supramolecular chemistry; SUPRAMOLECULAR CHEMISTRY; CUCURBITURIL; CAVITANDS; PROBE; SHAPE; TUBE;

D O I：

10.1002/anie.201807221

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Many biologically important compounds are amphiphilic in character. Glycolipids, for example, represent a biologically important class of amphiphiles. Receptors and sensors for such compounds must also be amphiphilic making them a challenge to prepare. Here, a cucurbit[8]uril (CB[8])-based sensor system has been prepared and tested for detection of amphiphilic compounds. This multi-component system consists: a CB[8], which acts as a hydrophobic lipid receptor, a hydrophilic pyridinium-based carbohydrate receptor, and a fluorescent indicator. The system self-assembles in aqueous solution. The pyridinium quenches the fluorescence of the indicator giving a strong turn-on response when it is displaced by the analyte. The sensor system was characterized by NMR, X-ray crystallography, and fluorescence titrations.

引用

页码：12741 / 12744

页数：4

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