Precision medicine in patients with allergic diseases: Airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology

被引：236

作者：

Muraro, Antonella ^{[1
]}

Lemanske, Robert F., Jr. ^{[2
]}

Hellings, Peter W. ^{[3
]}

Akdis, Cezmi A. ^{[4
]}

Bieber, Thomas ^{[5
]}

Casale, Thomas B. ^{[6
]}

Jutel, Marek ^{[7
,8
]}

Ong, Peck Y. ^{[9
,10
]}

Poulsen, Lars K. ^{[11
]}

Schmid-Grendelmeier, Peter ^{[12
,13
]}

Simon, Hans-Uwe ^{[14
]}

Seys, Sven F. ^{[15
]}

Agache, Ioana ^{[16
]}

机构：

[1] Padua Gen Univ Hosp, Dept Women & Child Hlth, Food Allergy Referral Ctr Veneto Reg, Padua, Italy

[2] Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI 53706 USA

[3] Univ Hosp Leuven, Dept Otorhinolaryngol, Louvain, Belgium

[4] Univ Zurich, Christine Kuhne Ctr Allergy Res & Educ, Swiss Inst Allergy & Asthma Res, Davos, Switzerland

[5] Univ Bonn, Christine Kuhne Ctr Allergy Res & Educ, Dept Dermatol & Allergy, Bonn, Germany

[6] Univ S Florida, Dept Internal Med, Tampa, FL 33612 USA

[7] Wroclaw Med Univ, Dept Clin Immunol, Wroclaw, Poland

[8] ALL MED Med Res Inst, Wroclaw, Poland

[9] Childrens Hosp Los Angeles, Div Clin Immunol & Allergy, Los Angeles, CA 90027 USA

[10] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[11] Copenhagen Univ Hosp Gentofte, Allergy Clin, Copenhagen, Denmark

[12] Univ Zurich, Dept Dermatol, Allergy Unit, Zurich, Switzerland

[13] Christine Kuhne Ctr Allergy Res & Educ, Davos, Switzerland

[14] Univ Bern, Inst Pharmacol, CH-3012 Bern, Switzerland

[15] Univ Leuven, Clin Immunol Lab, Louvain, Belgium

[16] Transylvania Univ Brasov, Dept Allergy & Clin Immunol, Brasov, Romania

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2016年 / 137卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

Precision medicine; personalized care; phenotype; endotype; biomarker; allergic rhinitis; allergic asthma; allergic skin disease; SEVERE EOSINOPHILIC ASTHMA; SURROGATE END-POINTS; DOUBLE-BLIND; CORTICOSTEROID RESPONSIVENESS; INTERNATIONAL CONSENSUS; CHRONIC RHINOSINUSITIS; IL-13; EXPRESSION; BARRIER FUNCTION; EVALUATE SAFETY; GENE-EXPRESSION;

D O I：

10.1016/j.jaci.2016.03.010

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In this consensus document we summarize the current knowledge on major asthma, rhinitis, and atopic dermatitis endotypes under the auspices of the PRACTALL collaboration platform. PRACTALL is an initiative of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology aiming to harmonize the European and American approaches to best allergy practice and science. Precision medicine is of broad relevance for the management of asthma, rhinitis, and atopic dermatitis in the context of a better selection of treatment responders, risk prediction, and design of disease-modifying strategies. Progress has been made in profiling the type 2 immune response-driven asthma. The endotype driven approach for non-type 2 immune response asthma, rhinitis, and atopic dermatitis is lagging behind. Validation and qualification of biomarkers are needed to facilitate their translation into pathway-specific diagnostic tests. Wide consensus between academia, governmental regulators, and industry for further development and application of precision medicine in management of allergic diseases is of utmost importance. Improved knowledge of disease pathogenesis together with defining validated and qualified biomarkers are key approaches to precision medicine.

引用

页码：1347 / 1358

页数：12

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