MAOA genotype modulates default mode network deactivation during inhibitory control

被引：10

作者：

Ma, Ren ^{[1
]}

Gan, Gabriela ^{[4
]}

Zhang, Jibiao ^{[1
]}

Ming, Qingsen ^{[1
]}

Jiang, Yali ^{[1
]}

Gao, Yidian ^{[1
]}

Wang, Xiang ^{[1
]}

Yao, Shuqiao ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Med Psychol Inst, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China

[2] Cent S Univ, Natl Technol Inst Psychiat, Changsha, Hunan, Peoples R China

[3] Cent S Univ, Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha, Hunan, Peoples R China

[4] Heidelberg Univ, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Syst Neurosci Psychiat,Med Fac Mannheim, Mannheim, Germany

来源：

BIOLOGICAL PSYCHOLOGY | 2018年 / 138卷

关键词：

MAOA gene; Aggression; Inhibitory control; Default mode network; MONOAMINE OXIDASE-A; INFERIOR FRONTAL-CORTEX; STOP SIGNAL TASK; AGGRESSIVE-BEHAVIOR; RESPONSE-INHIBITION; FUNCTIONAL CONNECTIVITY; PREFRONTAL CORTEX; CONDUCT DISORDER; RESTING-STATE; BRAIN;

D O I：

10.1016/j.biopsycho.2018.08.006

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

It has been demonstrated, in a long line of research, that the low-activity genotype of the monoamine oxidase A (MAOA) gene is associated with aggression. Previous work has linked impaired response inhibition to aggression, but little is known about how this relates to the purported MAOA-aggression relationship in adolescents. Here, we examined how MAOA genotype influences neural correlates of inhibitory control in 74 healthy male adolescents using a GoStop and a Go/Nogo task while differentiating between action cancelation and action restraint. Carriers of the low-expressing MAOA alleles (MAOA-L) did not show altered brain activation in the prefrontal-subcortical inhibition network relative to carriers of the high-expressing alleles across inhibition conditions. However, they exhibited a more pronounced deactivation during response inhibition in the posterior cingulate cortex (PCC) and precuneus, areas belonging to the default mode network (DMN). Larger DMN suppression in MAOA-L carriers might represent a compensation mechanism for impaired cognitive control.

引用

页码：27 / 34

页数：8

共 66 条

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