The Potential Influence of Plant Polyphenols on the Aging Process

被引：22

作者：

Cherniack, E. Paul ^{[1
,2
,3
,4
]}

机构：

[1] Miami VA Med Ctr, Div Geriatr & Gerontol, Miami, FL 33125 USA

[2] Miami VA Med Ctr, Geriatr & Extended Care Serv, Miami, FL 33125 USA

[3] Miami VA Med Ctr, Clin Ctr GRECC, Miami, FL 33125 USA

[4] Univ Miami, Miller Sch Med, Geriatr Inst, Miami, FL 33136 USA

来源：

FORSCHENDE KOMPLEMENTARMEDIZIN | 2010年 / 17卷 / 04期

关键词：

Plant; Polyphenol; Aging; Lifespan; LIFE-SPAN; CAENORHABDITIS-ELEGANS; CALORIC RESTRICTION; IN-VITRO; S-PHASE; RESVERATROL; CURCUMIN; QUERCETIN; BIOAVAILABILITY; INHIBITION;

D O I：

10.1159/000319143

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Cellular senescence is characterized by cellular hypertrophy: cell growth in the absence of cell division. The genes that regulate this process can be activated or inactivated by numerous plant polyphenols such as resveratrol, quercetin, butein, fistein, piceatannol, curcumin. Many of these substances have been shown to lengthen the lifespan of invertebrates. Many of these compounds have other potential beneficial effects on lifespan as antiatherogenic or antineoplastic agents. Challenges to human testing of such substances on lifespan include determination of dosage, low bioavailability, time and resources necessary to conduct tests, and understanding which formulation of substances to use.

引用

页码：181 / 187

页数：7

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