Experimental measurement and thermodynamic models for solid-liquid equilibrium of hyodeoxycholic acid in different organic solvents

被引：17

作者：

Yang, Yang ^{[1
]}

Hu, Yonghong ^{[1
]}

Zhang, Qi ^{[1
]}

Cheng, Limin ^{[1
]}

Cao, Cuicui ^{[1
]}

Yang, Wenge ^{[1
]}

Shen, Fei ^{[2
]}

机构：

[1] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Xinbai Pharmaceut Co Ltd, Nanjing 210038, Jiangsu, Peoples R China

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2015年 / 202卷

关键词：

Hyodeoxycholic acid; Apelblat model; lambda h model; Ideal model; Thermodynamic parameters; SOLUBILITY; WATER; MIXTURES; ETHANOL;

D O I：

10.1016/j.molliq.2014.12.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Data on corresponding solid-liquid equilibrium of hyodeoxycholic add (HDCA) in different solvents is essential for a preliminary study of industrial applications. In this paper, the solid-liquid equilibrium of HDCA in methanol, ethanol, isopropyl alcohol, butan-1-ol, ethyl acetate, acetone, acetonitrile, and acetic acid was explored at temperatures ranging from 278.15 to 333.15 K under atmosphere pressure. For the temperature range investigated, the solubility of HDCA in the solvents increased with increasing temperature. The modified Apelblat model, the Buchowski-Ksiazaczak lambda h model, and ideal model were adopted to describe and predict the change tendency of solubility. Besides, the calculated thermodynamic parameters indicated that in each studied solvent the dissolution process of HDCA is endothermic. Based on the analysis above, ethanol is considered to be the best solvent in crystallization process of HDCA. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：17 / 22

页数：6

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