Massive sertraline overdose

被引:18
作者
Brendel, DH
Bodkin, JA
Yang, JM
机构
[1] Massachusetts Gen Hosp, Dept Lab Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
[3] McLean Hosp, Dept Psychiat, Belmont, MA 02178 USA
关键词
D O I
10.1067/mem.2000.111575
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Selective serotonin reuptake inhibitor medications are considered relatively safe even in overdose. We report a massive overdose of sertraline with the highest serum sertraline concentration reported to date. Clinical features of this patient were confusion, agitation, myoclonus, hyperreflexia, fever, and creatine kinase elevation. This case may represent serotonin syndrome caused by sertraline overdose alone.
引用
收藏
页码:524 / 526
页数:3
相关论文
共 15 条
[1]  
[Anonymous], 1995, DISPOSITION TOXIC DR
[2]   Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome [J].
Bertorini, TE .
NEUROLOGIC CLINICS, 1997, 15 (03) :649-+
[3]   SEROTONIN SYNDROME [J].
BODNER, RA ;
LYNCH, T ;
LEWIS, L ;
KAHN, D .
NEUROLOGY, 1995, 45 (02) :219-223
[4]   Massive sertraline overdose [J].
Brendel, DH ;
Bodkin, JA ;
Yang, JM .
ANNALS OF EMERGENCY MEDICINE, 2000, 36 (05) :524-526
[5]  
Kolecki Paul, 1997, Journal of Emergency Medicine, V15, P491, DOI 10.1016/S0736-4679(97)00078-4
[6]   Selective serotonin reuptake inhibitor-induced serotonin syndrome: Review [J].
Lane, R ;
Baldwin, D .
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1997, 17 (03) :208-221
[7]   SEROTONIN SYNDROME-LIKE SYMPTOMS IN A PATIENT WITH OBSESSIVE-COMPULSIVE DISORDER, FOLLOWING INAPPROPRIATE INCREASE IN FLUVOXAMINE DOSAGE [J].
LENZI, A ;
RAFFAELLI, S ;
MARAZZITI, D .
PHARMACOPSYCHIATRY, 1993, 26 (03) :100-101
[8]  
Locurto Michael J., 1997, Emergency Medicine Clinics of North America, V15, P665, DOI 10.1016/S0733-8627(05)70324-2
[9]   Serotonin syndrome [J].
Martin, TG .
ANNALS OF EMERGENCY MEDICINE, 1996, 28 (05) :520-526
[10]   Fatal overdose with citalopram [J].
Ostrom, M ;
Eriksson, A ;
Thorson, J ;
Spigset, O .
LANCET, 1996, 348 (9023) :339-340