Group sequential designs using both type I and type II error probability spending functions

被引：20

作者：

Chang, MN

Hwang, IK

Shih, WCJ

机构：

[1] Univ Florida, Dept Stat, Gainesville, FL 32611 USA

[2] Merck Res Labs, Biostat & Res Data Syst, Rahway, NJ 07065 USA

来源：

COMMUNICATIONS IN STATISTICS-THEORY AND METHODS | 1998年 / 27卷 / 06期

关键词：

flexible group sequential designs; error spending functions; information times; decision boundaries;

D O I：

10.1080/03610929808832161

中图分类号：

O21 [概率论与数理统计]; C8 [统计学];

学科分类号：

020208 ; 070103 ; 0714 ;

摘要：

We propose flexible group sequential designs using type I and type II error probability spending functions. The proposed designs preserve the overall significance level and power and allow the repeated testing to be performed at a flexible schedule. Computational methods are described. An example on a mega clinical trial is provided.

引用

页码：1323 / 1339

页数：17

共 12 条

[1]

*CYT SOFTW CORP, 1992, SOFTW PACK DES INT M

[2] SYMMETRIC GROUP SEQUENTIAL TEST DESIGNS [J].