Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

被引：45

作者：

Dhaunchak, Ajit Singh ^{[2
,3
]}

Becker, Christopher ^{[4
,5
]}

Schulman, Howard ^{[4
,5
]}

De Faria, Omar, Jr. ^{[2
,3
]}

Rajasekharan, Sathyanath ^{[2
,6
]}

Banwell, Brenda ^{[7
]}

Colman, David R. ^{[2
,3
]}

Bar-Or, Amit ^{[1
,2
,6
]}

机构：

[1] McGill Univ, Montreal Neurol Inst & Hosp, Neuroimmunol Unit, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

[2] McGill Univ, Ctr Hlth, Montreal, PQ H3A 2B4, Canada

[3] McGill Univ, Program NeuroEngn, Montreal, PQ H3A 2B4, Canada

[4] PPD Biomarker Discovery Inc, Menlo Pk, CA USA

[5] Capr Prote, Menlo Pk, CA USA

[6] McGill Univ, Montreal Neurol Inst & Hosp, Expt Therapeut Program, Montreal, PQ H3A 2B4, Canada

[7] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

来源：

ANNALS OF NEUROLOGY | 2012年 / 71卷 / 05期

关键词：

CENTRAL-NERVOUS-SYSTEM; RANVIER; DEMYELINATION; NEUROFASCIN; CHILDREN; NODES; OLIGODENDROCYTES; RETENTION; PROTEINS; MOLECULE;

D O I：

10.1002/ana.22693

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axonglial interactions in those children destined for diagnosis of MS. Ann Neurol 2012;

引用

页码：601 / 613

页数：13

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