Strained Ruthenium Complexes Are Potent Light-Activated Anticancer Agents

被引：438
作者：
Howerton, Brock S. [1 ]
Heidary, David K. [1 ]
Glazer, Edith C. [1 ]
机构：
[1] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 20期
关键词：
PHOTOSUBSTITUTION REACTIONS; DNA-BINDING; LIGAND; PHOTOCHEMISTRY; H-1-NMR; METAL; RING;
D O I：
10.1021/ja3009677
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Strained ruthenium (Ru) complexes have been synthesized and characterized as novel agents for photodynamic therapy (PDT). The complexes are inert until triggered by visible light, which induces ligand loss and covalent modification of DNA. An increase in cytotoxicity of 2 orders of magnitude is observed with light activation in cancer cells, and the compounds display potencies superior to cisplatin against 3D tumor spheroids. The use of intramolecular strain may be applied as a general paradigm to develop light-activated ruthenium complexes for PDT applications.
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收藏
页码：8324 / 8327
页数：4
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