Targeting p21 activated kinase 1 (Pak1) to PAKup Pancreatic Cancer

被引:8
作者
Jagadeeshan, Sankar [1 ,2 ]
Venkatraman, Ganesh [3 ]
Rayala, Suresh K. [1 ]
机构
[1] IIT Madras, Dept Biotechnol, Madras, Tamil Nadu, India
[2] Univ Madras, Dept Genet, Madras, Tamil Nadu, India
[3] Sri Ramachandra Univ, Dept Human Genet, Madras, Tamil Nadu, India
关键词
Pak1; pancreatic adenocarcinoma; gemcitabine resistance; inhibitors; SMALL-MOLECULE INHIBITOR; PATHWAYS; KINASES; FRAX597;
D O I
10.1080/14728222.2016.1239719
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1283 / 1285
页数:3
相关论文
共 20 条
  • [1] ALAZAYZIH A, 2016, NANOMEDICINE, V21, P1231
  • [2] Molecular Pathways: Targeting RAC-p21-Activated Serine-Threonine Kinase Signaling in RAS-Driven Cancers
    Baker, Nicole M.
    Chow, Hoi Yee
    Chernoff, Jonathan
    Der, Channing J.
    [J]. CLINICAL CANCER RESEARCH, 2014, 20 (18) : 4740 - 4746
  • [3] p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model
    Chow, Hoi Yee
    Jubb, Adrian M.
    Koch, Jennifer N.
    Jaffer, Zahara M.
    Stepanova, Dina
    Campbell, David A.
    Duron, Sergio G.
    O'Farrell, Marie
    Cai, Kathy Q.
    Klein-Szanto, Andres J. P.
    Gutkind, J. Silvio
    Hoeflich, Klaus P.
    Chernoff, Jonathan
    [J]. CANCER RESEARCH, 2012, 72 (22) : 5966 - 5975
  • [4] An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    Deacon, Sean W.
    Beeser, Alexander
    Fukui, Jami A.
    Rennefahrt, Ulrike E. E.
    Myers, Cynthia
    Chernoff, Jonathan
    Peterson, Jeffrey R.
    [J]. CHEMISTRY & BIOLOGY, 2008, 15 (04): : 322 - 331
  • [5] Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer-Opportunities, Challenges, and Limitations
    Eswaran, Jeyanthy
    Li, Da-Qiang
    Shah, Anil
    Kumar, Rakesh
    [J]. CLINICAL CANCER RESEARCH, 2012, 18 (14) : 3743 - 3749
  • [6] Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies
    Haqq, Jonathan
    Howells, Lynne M.
    Garcea, Giuseppe
    Metcalfe, Matthew S.
    Steward, Will P.
    Dennison, Ashley R.
    [J]. EUROPEAN JOURNAL OF CANCER, 2014, 50 (15) : 2570 - 2582
  • [7] P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer
    Jagadeeshan, S.
    Subramanian, A.
    Tentu, S.
    Beesetti, S.
    Singhal, M.
    Raghavan, S.
    Surabhi, R. P.
    Mavuluri, J.
    Bhoopalan, H.
    Biswal, J.
    Pitani, R. S.
    Chidambaram, S.
    Sundaram, S.
    Malathi, R.
    Jeyaraman, J.
    Nair, A. S.
    Venkatraman, G.
    Rayala, S. K.
    [J]. ANNALS OF ONCOLOGY, 2016, 27 (08) : 1546 - 1556
  • [8] Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis
    Jagadeeshan, S.
    Krishnamoorthy, Y. R.
    Singhal, M.
    Subramanian, A.
    Mavuluri, J.
    Lakshmi, A.
    Roshini, A.
    Baskar, G.
    Ravi, M.
    Joseph, L. D.
    Sadasivan, K.
    Krishnan, A.
    Nair, A. S.
    Venkatraman, G.
    Rayala, S. K.
    [J]. ONCOGENE, 2015, 34 (04) : 455 - 464
  • [9] Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Jones, Sian
    Zhang, Xiaosong
    Parsons, D. Williams
    Lin, Jimmy Cheng-Ho
    Leary, Rebecca J.
    Angenendt, Philipp
    Mankoo, Parminder
    Carter, Hannah
    Kamiyama, Hirohiko
    Jimeno, Antonio
    Hong, Seung-Mo
    Fu, Baojin
    Lin, Ming-Tseh
    Calhoun, Eric S.
    Kamiyama, Mihoko
    Walter, Kimberly
    Nikolskaya, Tatiana
    Nikolsky, Yuri
    Hartigan, James
    Smith, Douglas R.
    Hidalgo, Manuel
    Leach, Steven D.
    Klein, Alison P.
    Jaffee, Elizabeth M.
    Goggins, Michael
    Maitra, Anirban
    Iacobuzio-Donahue, Christine
    Eshleman, James R.
    Kern, Scott E.
    Hruban, Ralph H.
    Karchin, Rachel
    Papadopoulos, Nickolas
    Parmigiani, Giovanni
    Vogelstein, Bert
    Velculescu, Victor E.
    Kinzler, Kenneth W.
    [J]. SCIENCE, 2008, 321 (5897) : 1801 - 1806
  • [10] Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor
    Karpov, Alexei S.
    Amiri, Payman
    Bellamacina, Cornelia
    Bellance, Marie-Helene
    Breitenstein, Werner
    Daniel, Dylan
    Denay, Regis
    Fabbro, Doriano
    Fernandez, Cesar
    Galuba, Inga
    Guerro-Lagasse, Stephanie
    Gutmann, Sascha
    Hinh, Linda
    Jahnke, Wolfgang
    Klopp, Julia
    Lai, Albert
    Lindvall, Mika K.
    Ma, Sylvia
    Moebitz, Henrik
    Pecchi, Sabina
    Rummel, Gabriele
    Shoemaker, Kevin
    Trappe, Joerg
    Voliva, Charles
    Cowan-Jacob, Sandra W.
    Marzinzik, Andreas L.
    [J]. ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (07): : 776 - 781