Objective: To describe characteristics of Parkinson's disease by sex and determine if differences in disease progression exist. Design: Longitudinal, observational study. Setting: Twenty-one National Parkinson Foundation Centers of Excellence. Participants: People (N = 4,679; 63% men and 37% women) with idiopathic Parkinson's disease. Methods: Demographic and clinical data at enrollment and after 1 year were collected. We defined progression as a 1-year change in the following functional health outcome measures: (a) health-related quality of life (Parkinson's Disease Questionnaire-39), (b) Timed Up and Go test, (c) cognitive function, and (d) number of medications. We compared baseline characteristics between men and women. Then, linear regression models were built to assess the independent contribution of sex to progression. Results: At baseline, women were significantly more likely to be older and have greater disease severity and more comorbidities than men despite similar duration of disease. This finding corresponded to worse function as assessed by the Parkinson's Disease Questionnaire-39 and Timed Up and Go test but not to number of medications and cognitive function. After 1 year, declines across all functional measures except delayed recall occurred. No significant changes in Parkinson's Disease Questionnaire-39, Timed Up and Go, number of medications, or verbal fluency between men and women occurred. Women had a more significant improvement in delayed recall than men. Conclusion: Numerous small baseline differences occurred between men and women with PD, although differences in markers of progression were few. Findings suggest that clinical manifestations and prognosis appear similar by sex under the same treatment conditions.
机构:
Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USABoston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
Houle, Nichole
Feaster, Taylor
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USABoston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
Feaster, Taylor
Mira, Amna
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
King Saud bin Abdulaziz Univ Hlth Sci, Coll Appl Med Sci, Jeddah, Saudi Arabia
King Abdullah Int Med Res Ctr, Jeddah, Saudi ArabiaBoston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
Mira, Amna
Meeks, Kirsten
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USABoston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
Meeks, Kirsten
Stepp, Cara E.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
Boston Univ, Dept Biomed Engn, Boston, MA USA
Boston Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Boston, MA USABoston Univ, Dept Speech Language & Hearing Sci, Boston, MA 02215 USA
机构:
Univ Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Ferreira, Luiz Philipe de Souza
Silva, Rafael Andre da
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estadual Paulista IBILCE UNESP, Biosci Grad Program, Inst Biociencias Letras & Ciencias Exatas, Sao Jose do Rio Preto, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Silva, Rafael Andre da
Costa, Matheus Marques Mesquita da
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Ceara UFC, Med Sci Grad Program, Fortaleza, CE, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Costa, Matheus Marques Mesquita da
Roda, Vinicius Moraes de Paiva
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sa Paulo ICB USP, Life Syst Biol Grad Program, Inst Ciencias Biomed, Sa Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Roda, Vinicius Moraes de Paiva
Vizcaino, Santiago
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dept Ophthalmol, Dallas, TX USAUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Vizcaino, Santiago
Janisset, Nilma R. L. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo EPM UNIFESP, Dept Pharmacol, Escola Paulista Med, Sa Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Janisset, Nilma R. L. L.
Vieira, Renata Ramos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Vieira, Renata Ramos
Sanchese, Jose Marcos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr, Dept Ophthalmol, Dallas, TX USAUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Sanchese, Jose Marcos
Soares Junior, Jose Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo FMUSP, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
Soares Junior, Jose Maria
Simoesa, Manuel de Jesus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, BrazilUniv Fed Sao Paulo EPM UNIFESP, Struct & Funct Biol Grad Program, Escola Paulista Med, Sa Paulo, Brazil
机构:
Univ Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
de Souza Ferreira, Luiz Philipe
da Silva, Rafael Andre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Estadual Paulista IBILCE UNESP, Inst Biociencias Letras & Ciencias Exatas, Biosci Grad Program, Sao Jose Do Rio Preto, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
da Silva, Rafael Andre
Mesquita da Costa, Matheus Marques
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Ceara UFC, Med Sci Grad Program, Fortaleza, Ceara, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Mesquita da Costa, Matheus Marques
de Paiva Roda, Vinicius Moraes
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo ICB USP, Inst Ciencias Biomed, Life Syst Biol Grad Program, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
de Paiva Roda, Vinicius Moraes
Vizcaino, Santiago
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Dept Ophthalmol, Dallas, TX USAUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Vizcaino, Santiago
Janisset, Nilma R. L. L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo EPM UNIFESP, Dept Pharmacol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Janisset, Nilma R. L. L.
Vieira, Renata Ramos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Vieira, Renata Ramos
Sanches, Jose Marcos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Southwestern Med Ctr Dallas, Dept Ophthalmol, Dallas, TX USAUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Sanches, Jose Marcos
Soares Junior, Jose Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sao Paulo FMUSP, Fac Med, Dept Obstet & Gynecol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
Soares Junior, Jose Maria
Simoes, Manuel de Jesus
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, EPM UNIFESP, Escola Paulista Med, Struct & Funct Biol Grad Program, Sao Paulo, SP, Brazil
机构:
Univ Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, Brazil
de la Rosa, Tomas
Scerni, Debora Amado
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, Brazil
Scerni, Debora Amado
Scorza, Fulvio Alexandre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Neurol, Escola Paulista Med, BR-04039032 Sao Paulo, Brazil