Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

被引:73
作者
Neu, Karlynn E. [1 ]
Dunand, Carole J. Henry [2 ]
Wilson, Patrick C. [1 ,2 ]
机构
[1] Univ Chicago, Comm Immunol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Med, Rheumatol Sect, Knapp Ctr Lupus & Immunol Res, 5841 S Maryland Ave, Chicago, IL 60637 USA
基金
美国国家卫生研究院;
关键词
RECEPTOR-BINDING SITE; CONSERVED NEUTRALIZING EPITOPE; VIRUS HEMAGGLUTININ; A VIRUSES; MONOCLONAL-ANTIBODIES; H5N1; VACCINATION; GLOBULAR HEAD; NEURAMINIDASE; RECOGNITION; RESPONSES;
D O I
10.1016/j.coi.2016.05.012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Current seasonal influenza virus vaccines are effective against infection but they have to be reformulated on a regular basis to counter antigenic variations. The majority of the antibodies induced in response to seasonal vaccination are strain specific. However, antibodies targeting conserved epitopes on the hemagglutinin protein have been identified and they offer broad protection. Most of these antibodies bind the hemagglutinin stalk domain and are generated from preexisting memory B cells. Broadly protective stalk-biased responses induced by antigenically divergent influenza strains, in concert with prior immunity, are sufficient to eradicate seasonally circulating strains. Future vaccine trials should aim to harness and maintain such a response with the realistic goal of developing a universal influenza vaccine.
引用
收藏
页码:48 / 55
页数:8
相关论文
共 91 条
  • [1] Influenza neuraminidase
    Air, Gillian M.
    [J]. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2012, 6 (04) : 245 - 256
  • [2] SEQUENCE RELATIONSHIPS AMONG THE HEMAGGLUTININ GENES OF 12 SUBTYPES OF INFLUENZA-A VIRUS
    AIR, GM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (12): : 7639 - 7643
  • [3] Immune history profoundly affects broadly protective B cell responses to influenza
    Andrews, Sarah F.
    Huang, Yunping
    Kaur, Kaval
    Popova, Lyubov I.
    Ho, Irvin Y.
    Pauli, Noel T.
    Dunand, Carole J. Henry
    Taylor, William M.
    Lim, Samuel
    Huang, Min
    Qu, Xinyan
    Lee, Jane-Hwei
    Salgado-Ferrer, Marlene
    Krammer, Florian
    Palese, Peter
    Wrammert, Jens
    Ahmed, Rafi
    Wilson, Patrick C.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (316)
  • [4] Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses
    Avnir, Yuval
    Tallarico, Aimee S.
    Zhu, Quan
    Bennett, Andrew S.
    Connelly, Gene
    Sheehan, Jared
    Sui, Jianhua
    Fahmy, Amr
    Huang, Chiung-yu
    Cadwell, Greg
    Bankston, Laurie A.
    McGuire, Andrew T.
    Stamatatos, Leonidas
    Wagner, Gerhard
    Liddington, Robert C.
    Marasco, Wayne A.
    [J]. PLOS PATHOGENS, 2014, 10 (05)
  • [5] Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine
    Babu, Tara M.
    Levine, Min
    Fitzgerald, Theresa
    Luke, Catherine
    Sangster, Mark Y.
    Jin, Hong
    Topham, David
    Katz, Jacqueline
    Treanor, John
    Subbarao, Kanta
    [J]. VACCINE, 2014, 32 (50) : 6798 - 6804
  • [6] STRUCTURE OF INFLUENZA HEMAGGLUTININ AT THE PH OF MEMBRANE-FUSION
    BULLOUGH, PA
    HUGHSON, FM
    SKEHEL, JJ
    WILEY, DC
    [J]. NATURE, 1994, 371 (6492) : 37 - 43
  • [7] A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins
    Corti, Davide
    Voss, Jarrod
    Gamblin, Steven J.
    Codoni, Giosiana
    Macagno, Annalisa
    Jarrossay, David
    Vachieri, Sebastien G.
    Pinna, Debora
    Minola, Andrea
    Vanzetta, Fabrizia
    Silacci, Chiara
    Fernandez-Rodriguez, Blanca M.
    Agatic, Gloria
    Bianchi, Siro
    Giacchetto-Sasselli, Isabella
    Calder, Lesley
    Sallusto, Federica
    Collins, Patrick
    Haire, Lesley F.
    Temperton, Nigel
    Langedijk, Johannes P. M.
    Skehel, John J.
    Lanzavecchia, Antonio
    [J]. SCIENCE, 2011, 333 (6044) : 850 - 856
  • [8] Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine
    Corti, Davide
    Suguitan, Amorsolo L., Jr.
    Pinna, Debora
    Silacci, Chiara
    Fernandez-Rodriguez, Blanca M.
    Vanzetta, Fabrizia
    Santos, Celia
    Luke, Catherine J.
    Torres-Velez, Fernando J.
    Temperton, Nigel J.
    Weiss, Robin A.
    Sallusto, Federica
    Subbarao, Kanta
    Lanzavecchia, Antonio
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (05) : 1663 - 1673
  • [9] de Jong JC, 2000, J MED VIROL, V61, P94, DOI 10.1002/(SICI)1096-9071(200005)61:1<94::AID-JMV15>3.0.CO
  • [10] 2-C