Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms

被引：203

作者：

Houchin, M. L. ^{[1
,2
]}

Topp, E. M. ^{[1
]}

机构：

[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66045 USA

[2] Amylin Pharmaceut Inc, San Diego, CA 92121 USA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 97卷 / 07期

关键词：

PLGA; hydrolysis; deamidation; acylation; peptide stability;

D O I：

10.1002/jps.21176

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed. (C) 2007 Wiley-Liss, Inc.

引用

页码：2395 / 2404

页数：10

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