Chemical degradation of peptides and proteins in PLGA: A review of reactions and mechanisms

被引：200
作者：
Houchin, M. L. [1 ,2 ]
Topp, E. M. [1 ]
机构：
[1] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66045 USA
[2] Amylin Pharmaceut Inc, San Diego, CA 92121 USA
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 97卷 / 07期
关键词：
PLGA; hydrolysis; deamidation; acylation; peptide stability;
D O I：
10.1002/jps.21176
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Biodegradable poly(lactide-co-glycolide) (PLGA) polymers have been studied extensively for the controlled release of peptide and protein drugs. In addition to polymer biodegradation, chemical degradation of the incorporated peptide/protein has also been reported in PLGA devices, and the role of the polymer in promoting these reactions has been debated. This review summarizes the peptide/protein chemical degradation reactions that have been reported in PLGA systems and their mechanisms. Reported methods for stabilizing peptides and proteins in PLGA devices are also discussed. (C) 2007 Wiley-Liss, Inc.
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收藏
页码：2395 / 2404
页数：10
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