Basal ganglia germinoma:: Diagnostic value of MR spectroscopy and 11C-methionine positron emission tomography

被引：17
作者：
Fujii, Yuji [1 ]
Saito, Yoshiaki [1 ]
Ogawa, Toshihide [2 ]
Fujii, Shinya [2 ]
Kamitani, Hideki [3 ]
Kondo, Shinji [3 ]
Horie, Yasushi [4 ]
Togawa, Masami [5 ]
Senda, Michio [6 ]
Maegaki, Yoshihiro [1 ]
Ohno, Kousaku [1 ]
机构：
[1] Tottori Univ, Fac Med, Inst Neurol Sci, Div Child Neurol, Yonago, Tottori 6838504, Japan
[2] Tottori Univ, Fac Med, Div Radiol, Yonago, Tottori 6838504, Japan
[3] Tottori Univ, Fac Med, Inst Neurol Sci, Dept Neurosurg, Yonago, Tottori 6838504, Japan
[4] Tottori Univ Hosp, Div Pathol, Tottori, Japan
[5] Tottori Prefectural Cent Hosp, Dept Pediat, Tottori, Japan
[6] Inst Biomed Res & Innovat, Kobe, Hyogo, Japan
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 270卷 / 1-2期
关键词：
germinoma; basal ganglia; childhood; magnetic resonance spectroscopy; (11)C-methionine positron emission tomography; basal ganglia atrophy;
D O I：
10.1016/j.jns.2008.02.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We herein report a 12-year-old girl with a basal ganglia germinoma who presented with right-sided hemiparesis after a minor head trauma. Magnetic resonance (MR) imaging revealed a minimally enhanced lesion involving the left putamen, thalamus, and corona radiata. The lesion showed low-signal intensity on T1-, and high intensity on T2- and diffusion-weighted imaging. The MR signal in the adjacent globus pallidum was also low on T2-weighted imaging. MR spectroscopy on the lesion showed a large lactate/lipid/macromolecule peak with a decreased NAA/Cr ratio, but no increase in the Cho/Cr ratio. However, posttraumatic infarction at the territory of lateral lenticulostriate artery was ruled out I month later. This was based on progression of the hemiparesis and neuromiaging results, including an increased Cho/Cr ratio and weak uptake on 11 C-methionine positron emission tomography of the basal ganglia lesion. Stereotaxic brain biopsy confirmed the diagnosis of germinoma. (C) 2008 Elsevier B.V.. All rights reserved.
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收藏
页码：189 / 193
页数：5
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