Multiple Sclerosis Mechanisms of Disease and Strategies for Myelin and Axonal Repair

被引：81

作者：

Lemus, Hernan Nicolas ^{[1
]}

Warrington, Arthur E. ^{[1
]}

Rodriguez, Moses ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Neurol, Guggenheim Bldg 401,200 First St Southwest, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Immunol, 200 First St Southwest, Rochester, MN 55905 USA

来源：

NEUROLOGIC CLINICS | 2018年 / 36卷 / 01期

关键词：

Multiple sclerosis; Autoimmune; Immune; Axon; Remyelination; CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; RECOMBINANT HUMAN-IGM; NEUROMYELITIS-OPTICA; OLIGODENDROCYTE GLYCOPROTEIN; T-CELLS; BASIC-PROTEIN; INFLAMMATORY DEMYELINATION; NATURAL AUTOANTIBODIES;

D O I：

10.1016/j.ncl.2017.08.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system with a variety of presentations and unclear pathogenesis. Multiple sclerosis has been associated with the term autoimmunity as a surrogate for pathogenesis. Multiple sclerosis is an organ-specific disease with immune-mediated myelin destruction. Understanding the complex etiology of multiple sclerosis and the importance of axon integrity is critical for clinicians who treat the disease. This article discusses the immune and autoimmune aspects of multiple sclerosis based on the current published data and novel evidence of strategies that promote remyelination and protect axons.

引用

页码：1 / +

页数：12

共 80 条

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