Regioselective Synthesis of N2-Aryl 1,2,3-Triazoles via Electro- oxidative Coupling of Enamines and Aryldiazonium Salts

被引：23

作者：

Baidya, Mrinmay ^{[1
]}

Mallick, Samrat ^{[1
]}

De Sarkar, Suman ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, W Bengal, India

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 06期

关键词：

N-BOND FORMATION; AZIDE-FREE SYNTHESIS; METAL-FREE; ANNULATION; DERIVATIVES; KETONES; ACCESS; ELECTROSYNTHESIS; TRIAZOLES; STRATEGY;

D O I：

10.1021/acs.orglett.1c04099

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic route for the construction of N-2-aryl 1,2,3-triazoles is reported via sequential C-N bond formation and electro-oxidative N-N coupling under metal-free conditions. Readily accessible 2-aminoacrylates and aryldiazonium salts were used as starting materials, and the developed protocol displays excellent functional group tolerance, allowing an extensive range of substrate scope up to 91% isolated yield. Various mechanistic studies, along with the isolation of an intermediate adduct, refer to successive ionic and radical reaction sequences.

引用

页码：1274 / 1279

页数：6

共 55 条

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