Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions

被引：28

作者：

Safari, Javad ^{[1
]}

Banitaba, Sayed Hossein ^{[1
]}

Khalili, Shiva Dehghan ^{[1
,2
]}

机构：

[1] Univ Kashan, Dept Organ Chem, Coll Chem, Organ Chem Res Lab, Kashan 8731751167, Iran

[2] Islamic Azad Univ, Najafabad Branch, Najafabad 8514143131, Iran

来源：

CHINESE JOURNAL OF CATALYSIS | 2011年 / 32卷 / 12期

关键词：

cobalt nanoparticle; 1,4-dihydropyridine; four-component condensation; heterogeneou catalyst; magnetically separable catalyst; ONE-STEP SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; HANTZSCH REACTION; COMBINATORIAL SYNTHESIS; CHANNEL ANTAGONISTS; HYDROFORMYLATION; CATALYST; FACILE; CONDENSATION; TEMPERATURE;

D O I：

10.1016/S1872-2067(10)60295-1

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A straightforward and general method has been developed for the synthesis of C(5)-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

引用

页码：1850 / 1855

页数：6

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