Tobacco, Alcohol and Family History of Cancer as Risk Factors of Oral Squamous Cell Carcinoma: Case-Control Retrospective Study

被引：38
作者：
Tenore, Gianluca [1 ,2 ]
Nuvoli, Alessandro [1 ,2 ]
Mohsen, Ahmed [1 ,2 ]
Cassoni, Andrea [1 ,2 ]
Battisti, Andrea [1 ,2 ]
Terenzi, Valentina [1 ,2 ]
Della Monaca, Marco [1 ,2 ]
Raponi, Ingrid [1 ,2 ]
Brauner, Edoardo [1 ,2 ]
De Felice, Francesca [1 ,3 ]
Musio, Daniela [1 ,3 ]
Di Gioia, Cira Rosaria Tiziana [1 ,3 ]
Messineo, Daniela [1 ,3 ]
Mezi, Silvia [1 ,3 ]
Di Carlo, Stefano [1 ,2 ]
Botticelli, Andrea [1 ,4 ]
Valentini, Valentino [1 ,2 ]
Marchetti, Paolo [1 ,4 ]
Tombolini, Vincenzo [1 ,3 ]
De Vincentiis, Marco [1 ,2 ]
Polimeni, Antonella [1 ,2 ]
Romeo, Umberto [1 ,2 ]
机构：
[1] Sapienza Univ Rome, Polyclin Umberto 1, Head & Neck Tumor Board, I-00161 Rome, Italy
[2] Sapienza Univ Rome, Dept Oral Sci & Maxillofacial Surg, I-00161 Rome, Italy
[3] Sapienza Univ Rome, Dept Radiol Sci Oncol & Anat Pathol, I-00161 Rome, Italy
[4] Sapienza Univ Rome, Dept Clin & Mol Med, I-00161 Rome, Italy
来源：
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 11期
关键词：
alcohol; family history of cancer; head and neck cancer; oral cancer; oral squamous cell carcinoma; smoking; tobacco; UPPER AERODIGESTIVE TRACT; NECK-CANCER; INTERNATIONAL HEAD; POOLED ANALYSIS; DRINKING; SMOKING; EPIDEMIOLOGY; WINE; CONSUMPTION; PATTERNS;
D O I：
10.3390/app10113896
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The aim of the study is to observe retrospectively the correlation between Oral Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG) consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and FHC; including the General Family History of Cancer (GFHC) and Family History of Head and Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco consumption was associated with an OR of 1.035 (95% CI 1.001-1.070) and a statistical significance (p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR was 1.035 (95% CI 1.010-1.061). The GFHC was associated with a marginal risk of OSCC with an OR of 1.095 (95% CI 0.953-1.259), without significance (p = 0.199). The FHHNC showed a notable risk increase with an OR of 1.871 (95% CI 0.902-3.882), without significance (p = 0.092). Alcohol and tobacco may be associated with an increase in the risk of OSCC.
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页数：11
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