Tobacco, Alcohol and Family History of Cancer as Risk Factors of Oral Squamous Cell Carcinoma: Case-Control Retrospective Study

被引：39

作者：

Tenore, Gianluca ^{[1
,2
]}

Nuvoli, Alessandro ^{[1
,2
]}

Mohsen, Ahmed ^{[1
,2
]}

Cassoni, Andrea ^{[1
,2
]}

Battisti, Andrea ^{[1
,2
]}

Terenzi, Valentina ^{[1
,2
]}

Della Monaca, Marco ^{[1
,2
]}

Raponi, Ingrid ^{[1
,2
]}

Brauner, Edoardo ^{[1
,2
]}

De Felice, Francesca ^{[1
,3
]}

Musio, Daniela ^{[1
,3
]}

Di Gioia, Cira Rosaria Tiziana ^{[1
,3
]}

Messineo, Daniela ^{[1
,3
]}

Mezi, Silvia ^{[1
,3
]}

Di Carlo, Stefano ^{[1
,2
]}

Botticelli, Andrea ^{[1
,4
]}

Valentini, Valentino ^{[1
,2
]}

Marchetti, Paolo ^{[1
,4
]}

Tombolini, Vincenzo ^{[1
,3
]}

De Vincentiis, Marco ^{[1
,2
]}

Polimeni, Antonella ^{[1
,2
]}

Romeo, Umberto ^{[1
,2
]}

机构：

[1] Sapienza Univ Rome, Polyclin Umberto 1, Head & Neck Tumor Board, I-00161 Rome, Italy

[2] Sapienza Univ Rome, Dept Oral Sci & Maxillofacial Surg, I-00161 Rome, Italy

[3] Sapienza Univ Rome, Dept Radiol Sci Oncol & Anat Pathol, I-00161 Rome, Italy

[4] Sapienza Univ Rome, Dept Clin & Mol Med, I-00161 Rome, Italy

来源：

APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 11期

关键词：

alcohol; family history of cancer; head and neck cancer; oral cancer; oral squamous cell carcinoma; smoking; tobacco; UPPER AERODIGESTIVE TRACT; NECK-CANCER; INTERNATIONAL HEAD; POOLED ANALYSIS; DRINKING; SMOKING; EPIDEMIOLOGY; WINE; CONSUMPTION; PATTERNS;

D O I：

10.3390/app10113896

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aim of the study is to observe retrospectively the correlation between Oral Squamous Cell Carcinoma (OSCC) and risk factors; including tobacco, alcohol and Family History of Cancer (FHC). A total of 478 patients were included retrospectively from the database of the Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome. A Test Group (TG) consisted of 239 patients with a confirmed diagnosis of OSCC. A Control Group (CG) consisted of 239 patients without history and/or diagnosis of oral cancer. The logistic regression models were used to calculate the adjusted Odd Ratios (ORs) associated with alcohol, tobacco and FHC; including the General Family History of Cancer (GFHC) and Family History of Head and Neck Cancer (FHHNC) and their 95% Confidence Intervals (CI). The high rate of tobacco consumption was associated with an OR of 1.035 (95% CI 1.001-1.070) and a statistical significance (p = 0.041). Drinker patients showed a significant risk of developing OSCC (p = 0.05) and the OR was 1.035 (95% CI 1.010-1.061). The GFHC was associated with a marginal risk of OSCC with an OR of 1.095 (95% CI 0.953-1.259), without significance (p = 0.199). The FHHNC showed a notable risk increase with an OR of 1.871 (95% CI 0.902-3.882), without significance (p = 0.092). Alcohol and tobacco may be associated with an increase in the risk of OSCC.

引用

页数：11

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