Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors

被引：27

作者：

Pullagurla, M

Siripurapu, U

Kolanos, R

Bondarev, ML

Dukat, M

Setola, V

Roth, BL

Glennon, RA ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA

[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Sch Med, Dept Psychiat & Neurosci, Cleveland, OH 44106 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 23期

关键词：

5-HT6 serotonin receptors; aminoindoles;

D O I：

10.1016/j.bmcl.2005.08.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An examination of several amine-substituted analogs of N-1-benzenesulfonylindoles reveals that although they bind at human 5-HT6 serotonin receptors with high affinity, they are likely to bind in a dissimilar manner. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5298 / 5302

页数：5

共 26 条

[1] ARS HOLDING NV, 2002, Patent No. 0232864
[2] 5-HT6 receptor antagonists:: lead optimisation and biological evaluation of N-aryl and N-heteroaryl 4-amino-benzene sulfonamides
Bös, M
Sleight, AJ
Godel, T
Martin, JR
Riemer, C
Stadler, H
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (02) : 165 - 178
[3] 5-chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzothiophenesulfonamide (SB-271046):: A potent, selective, and orally bioavailable 5-HT6 receptor antagonist
Bromidge, SM
Brown, AM
Clarke, SE
Dodgson, K
Gager, T
Grassam, HL
Jeffrey, PM
Joiner, GF
King, FD
Middlemiss, DN
Moss, SF
Newman, H
Riley, G
Routledge, C
Wyman, P
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (02) : 202 - 205
[4] Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists:: Identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)
Bromidge, SM
Clarke, SE
Gager, T
Griffith, K
Jeffrey, P
Jennings, AJ
Joiner, GF
King, FD
Lovell, PJ
Moss, SF
Newman, H
Riley, G
Rogers, D
Routledge, C
Serafinowska, H
Smith, DR
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (01) : 55 - 58
[5] INDOLE RELATED-COMPOUNDS - REACTION OF 1-PROTECTED-INDOLES WITH PYRIDINE SUBSTRATES
CAIXACH, J
CAPELL, R
GALVEZ, C
GONZALEZ, A
ROCA, N
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1979, 16 (08) : 1631 - 1635
[6] Discovery of 5-arylsulfonamido-3(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists
Cole, DC
Lennox, WJ
Lombardi, S
Ellingboe, JW
Bernotas, RC
Tawa, GJ
Mazandarani, H
Smith, DL
Zhang, GM
Coupet, J
Schechter, LE
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (02) : 353 - 356
[7] 2-Substituted tryptamines:: Agents with selectivity for 5-HT6 serotonin receptors
Glennon, RA
Lee, M
Rangisetty, JB
Dukat, M
Roth, BL
Savage, JE
McBride, A
Rauser, L
Hufeisen, S
Lee, DKH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (05) : 1011 - 1018
[8] Higher-end serotonin receptors:: 5-HT5, 5-HT6, and 5-HT7
Glennon, RA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (14) : 2795 - 2812
[9] Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling
Hirst, WD
Abrahamsen, B
Blaney, FE
Calver, AR
Aloj, L
Price, GW
Medhurst, AD
[J]. MOLECULAR PHARMACOLOGY, 2003, 64 (06) : 1295 - 1308
[10] Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands
Holenz, J
Mercè, R
Díaz, JL
Guitart, X
Codony, X
Dordal, A
Romero, G
Torrens, A
Mas, J
Andaluz, B
Hernández, S
Monroy, X
Sánchez, E
Hernández, E
Pérez, R
Cubí, R
Sanfeliu, O
Buschmann, H
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (06) : 1781 - 1795

← 1 2 3 →