N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Bromoenal and 1,3-Dicarbonyl Compounds

被引：179

作者：

Sun, Fang-Gang ^{[1
]}

Sun, Li-Hui ^{[1
]}

Ye, Song ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 17期

基金：

中国国家自然科学基金;

关键词：

annulation reactions; asymmetric catalysis; bromoenals; dihydropyranones; N-heterocyclic carbenes; INTRAMOLECULAR STETTER REACTION; DIELS-ALDER REACTIONS; ALPHA; BETA-UNSATURATED ALDEHYDES; GAMMA-BUTYROLACTONES; STEREOSELECTIVE-SYNTHESIS; NUCLEOPHILIC CARBENES; BENZOIN CONDENSATION; MICHAEL ADDITION; ESTERS; ENALS;

D O I：

10.1002/adsc.201100622

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Highly enantioselective [3+3] annulation reactions of bromoenals and 1,3-dicarbonyl compounds are reported. In addition, both enantiomers of the resultant dihydropyranone could be easily obtained by choosing N-heterocyclic carbenes (NHCs) with the same stereocenter but different substituents under the optimized reaction conditions.

引用

页码：3134 / 3138

页数：5

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