New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

被引：24

作者：

Hsiao, Ting-Hsi ^{[1
,2
]}

Sung, Chun-Sung ^{[3
,4
]}

Lan, Yu-Hsuan ^{[5
]}

Wang, Yi-Chen ^{[6
,7
]}

Lu, Mei-Chin ^{[1
,2
]}

Wen, Zhi-Hong ^{[6
]}

Wu, Yang-Chang ^{[5
,8
,9
,10
]}

Sung, Ping-Jyun ^{[1
,2
,6
,8
,9
]}

机构：

[1] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Taipei Vet Gen Hosp, Dept Anesthesiol, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[5] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[6] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[7] Kaohsiung Armed Forces Gen Hosp, Div Cardiol, Dept Internal Med, Kaohsiung 802, Taiwan

[8] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[9] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[10] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

来源：

MARINE DRUGS | 2015年 / 13卷 / 06期

关键词：

Nephthea columnaris; cembrane; octocoral; antiinflammatory; iNOS; COX-2; cytotoxicity; NITRIC-OXIDE SYNTHASE; DITERPENOIDS; INHIBITION; EXPRESSION;

D O I：

10.3390/md13063443

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods. In the anti-inflammatory effects test, cembranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Compound 1 exhibited moderate cytotoxicity toward LNCaP cells with an IC50 value of 9.80 g/mL.

引用

页码：3443 / 3453

页数：11

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