Preparation and characterization of a novel laminated magnetic hydroxyapatite for application on gene delivery

被引：20

作者：

Zuo, Guifu ^{[1
]}

Wan, Yizao ^{[2
]}

Zhang, Yu ^{[2
]}

机构：

[1] Hebei United Univ, Coll Mat Sci & Engn, Tangshan 063009, Peoples R China

[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

来源：

MATERIALS LETTERS | 2012年 / 68卷

关键词：

Nanocomposites; Microstructure; Laminates; NANOSTRUCTURED CALCIUM PHOSPHATES; DNA;

D O I：

10.1016/j.matlet.2011.10.079

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Two-dimensional layered materials exhibit desired functionalities when being used as gene delivery materials. In this study, a novel gene vector, laminated magnetic hydroxyapatite (LM-HAp), is synthesized through a templating method in situ. The prepared LM-HAp is characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and vibrating-sample magnetometry (VSM) analysis. The obtained data reveals that the LM-HAp exhibits an ordered laminated structure with ad spacing of 3.14 nm. Fe3O4 nanoparticles distribute uniformly on each of the HAp platelets. Moreover, LM-HAp possesses superparamagnetic property and exhibits a rapid response to an external magnetic field. The saturation magnetization of LM-HAp is 13.5 emu/g. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：225 / 227

页数：3

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