Anti-fibrotic and anti-inflammatory effects of parboiled germinated brown rice (Oryza sativa 'KDML 105') in rats with induced liver fibrosis

被引：12
作者：
Wunjuntuk, Kansuda [1 ,2 ]
Kettawan, Aikkarach [2 ]
Rungruang, Thanaporn [3 ]
Charoenkiatkul, Somsri [2 ]
机构：
[1] Kasetsart Univ, Dept Home Econ, Fac Agr, Bangkok 10900, Thailand
[2] Mahidol Univ, Inst Nutr, Food Chem Div, Nakhon Pathom 73170, Thailand
[3] Mahidol Univ, Fac Med, Dept Anat, Siriraj Hosp, Bangkok 10700, Thailand
来源：
JOURNAL OF FUNCTIONAL FOODS | 2016年 / 26卷
关键词：
Parboiled germinated brown rice; Inflammation; Liver fibrosis; OXIDATIVE STRESS; GAMMA-ORYZANOL; ACID; GABA; HEPATOTOXICITY; ANTIOXIDANT; POLYAMINES; CELLS; BETA;
D O I：
10.1016/j.jff.2016.08.009
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Parboiled germinated brown rice (PGBR) is produced by steaming germinated paddy rice of Khao Dawk Mali 105 Thai rice variety. We conducted the study to determine the anti fibrotic and anti-inflammatory effects of PGBR in rats induced by carbon tetrachloride (CCl4). Male Sprague-Dawley rats were randomly divided into five groups: (1) control group, (2) CCl4 group, (3) white rice (WR)+CCl4 group, (4) brown rice (BR)+CCl4 group, and (5) PGBR+CCl4 group. All rats except control group were orally administrated with CCl4 twice a week for 8 weeks. Rats in PGBR+CCI4 group showed the hepatoprotective effects by significantly decreasing the markers of liver inflammation (TNF-alpha, IL-6 and IL-1 beta), fibrosis (TGF-beta 1, PDGF), and hydroxyproline content, as well as the score of necro-inflammation and fibrosis. In addition, PGBR suppressed the expression level of a-smooth muscle actin significantly as compared with CCl4 group. These data suggested that regular consumption of PGBR could reduce liver inflammation and fibrosis. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：363 / 372
页数：10
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