Chelatable zinc modulates excitability and seizure duration in the amygdala rapid kindling model

被引：34

作者：

Foresti, Maira Licia ^{[1
]}

Arisi, Gabriel Maisonnave ^{[2
]}

Fernandes, Artur ^{[2
]}

Tilelli, Cristiane Queixa ^{[2
]}

Garcia-Cairasco, Norberto ^{[1
,2
]}

机构：

[1] Neurol Psychiat & Med Psychol Dept, Ribeirao Preto, Brazil

[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

EPILEPSY RESEARCH | 2008年 / 79卷 / 2-3期

基金：

巴西圣保罗研究基金会;

关键词：

epilepsy; DEDTC; hippocampus; EEG;

D O I：

10.1016/j.eplepsyres.2008.02.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Zinc is present in high concentration in many structures of the limbic circuitry, however the role of zinc as a neuromodulator in such synapses is stilt uncertain. In this work, we verified the effects of zinc chelation in an animal model of epileptogenesis induced by amygdala rapid kindling. The basolateral. amygdala was electrically stimulated ten times per day for 2 days. A single stimulus was applied on the third day. Stimulated animals received injections of PBS or the zinc chelator diethildythiocarbamate acid (DEDTC) before each stimulus series. Animals were monitored with video-EEG and were perfused 3 h after the last stimulus for subsequent neo-Timm and Ftuoro-Jade B analysis. Zinc chelation decreased the duration of both behavioral seizures and electrical after-discharges, and also decreased the EEG spikes frequency, without changing the progression of behavioral seizure severity. These results indicate that the zinc ion may have a facilitatory role during kindling progression. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：166 / 172

页数：7

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