Dendritic cells (DCs) are central player in immunity by bridging the innate and adaptive arms of the immune system (IS). Interferons (IFNs) are one of the most important factors that regulate both innate and adaptive immunity too. Thus, the understanding of how type II and I IFNs modulate the immune-regulatory properties of DCs is a central issue in immunology. In this paper, we will address this point in the light of the most recent literature, also highlighting the controversial data reported in the field. According to the wide literature available, type II as well as type I IFNs appear, at the same time, to collaborate, to induce additive effects or overlapping functions, as well as to counterregulate each one's effects on DC biology and, in general, the immune response. The knowledge of these effects has important therapeutic implications in the treatment of infectious/autoimmune diseases and cancer and indicates strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic approaches.
机构:
Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Arimoto-Miyamoto, Kazue
;
Kadowaki, Norimitsu
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Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kadowaki, Norimitsu
;
Kitawaki, Toshio
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Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kitawaki, Toshio
;
Iwata, Satoshi
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Univ Tokyo, Inst Med Sci, Div Clin Immunol, Adv Clin Res Ctr, Tokyo, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Iwata, Satoshi
;
Morimoto, Chikao
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Univ Tokyo, Inst Med Sci, Div Clin Immunol, Adv Clin Res Ctr, Tokyo, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Morimoto, Chikao
;
Uchiyama, Takashi
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Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, Japan
Tazuke Kofukai Med Res Inst, Osaka, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
机构:
Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Arimoto-Miyamoto, Kazue
;
Kadowaki, Norimitsu
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kadowaki, Norimitsu
;
Kitawaki, Toshio
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kitawaki, Toshio
;
Iwata, Satoshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Div Clin Immunol, Adv Clin Res Ctr, Tokyo, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Iwata, Satoshi
;
Morimoto, Chikao
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Div Clin Immunol, Adv Clin Res Ctr, Tokyo, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Morimoto, Chikao
;
Uchiyama, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan
Kyoto Univ, Dept Oncol, Grad Sch Med, Kyoto 6068507, Japan
Tazuke Kofukai Med Res Inst, Osaka, JapanKyoto Univ, Dept Haematol, Grad Sch Med, Kyoto 6068507, Japan