Overlapping, Additive and Counterregulatory Effects of Type II and I Interferons on Myeloid Dendritic Cell Functions

被引:6
作者
Frasca, Loredana [1 ]
Lande, Roberto [1 ]
机构
[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy
来源
THESCIENTIFICWORLDJOURNAL | 2011年 / 11卷
关键词
IFNs; dendritic cell effector functions; immune activation; immune regulation; cross-regulation; HEPATITIS-C VIRUS; T-HELPER TYPE-1; SUPPRESS MACROPHAGE ACTIVATION; ENABLES LISTERIA-MONOCYTOGENES; ANTIGEN-PRESENTING CELLS; IFN-GAMMA-PRODUCTION; NK CELLS; DIFFERENTIAL EXPRESSION; SIGNALING PATHWAYS; IMMUNE-RESPONSES;
D O I
10.1100/2011/873895
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Dendritic cells (DCs) are central player in immunity by bridging the innate and adaptive arms of the immune system (IS). Interferons (IFNs) are one of the most important factors that regulate both innate and adaptive immunity too. Thus, the understanding of how type II and I IFNs modulate the immune-regulatory properties of DCs is a central issue in immunology. In this paper, we will address this point in the light of the most recent literature, also highlighting the controversial data reported in the field. According to the wide literature available, type II as well as type I IFNs appear, at the same time, to collaborate, to induce additive effects or overlapping functions, as well as to counterregulate each one's effects on DC biology and, in general, the immune response. The knowledge of these effects has important therapeutic implications in the treatment of infectious/autoimmune diseases and cancer and indicates strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic approaches.
引用
收藏
页码:2071 / 2090
页数:20
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