Fabrication and Manipulation of Non-Spherical Particles in Microfluidic Channels: A Review

被引：15
作者：
Jiang, Di [1 ,2 ]
Liu, Shaowei [1 ]
Tang, Wenlai [3 ]
机构：
[1] Nanjing Forestry Univ, Coll Mech & Elect Engn, Nanjing 210037, Peoples R China
[2] Jiangsu Yuyue Med Equipment & Supply Co Ltd, Danyang 212300, Peoples R China
[3] Nanjing Normal Univ, Sch Elect & Automat Engn, Jiangsu Key Lab 3D Printing Equipment & Mfg, Nanjing 210023, Peoples R China
来源：
MICROMACHINES | 2022年 / 13卷 / 10期
基金：
中国博士后科学基金;
关键词：
microfluidics; non-spherical particle; particle manipulation; DISCRETIZED BOLTZMANN-EQUATION; PINCHED FLOW FRACTIONATION; NUMERICAL SIMULATIONS; CONTINUOUS SEPARATION; BLOOD-CELLS; PARTICULATE SUSPENSIONS; INERTIAL MIGRATION; POISEUILLE FLOW; LAMINAR-FLOW; SHAPE;
D O I：
10.3390/mi13101659
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Non-spherical shape is a general appearance feature for bioparticles. Therefore, a mechanical mechanism study of non-spherical particle migration in a microfluidic chip is essential for more precise isolation of target particles. With the manipulation of non-spherical particles, refined disease detection or medical intervention for human beings will be achievable in the future. In this review, fabrication and manipulation of non-spherical particles are discussed. Firstly, various fabrication methods for non-spherical microparticle are introduced. Then, the active and passive manipulation techniques for non-spherical particles are briefly reviewed, including straight inertial microchannels, secondary flow inertial microchannels and deterministic lateral displacement microchannels with extremely high resolution. Finally, applications of viscoelastic flow are presented which obviously increase the precision of non-spherical particle separation. Although various techniques have been employed to improve the performance of non-spherical particle manipulation, the universal mechanism behind this has not been fully discussed. The aim of this review is to provide a reference for non-spherical particle manipulation study researchers in every detail and inspire thoughts for non-spherical particle focused device design.
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页数：19
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