Breast cancer: Biology, biomarkers, and treatments

被引：489

作者：

Barzaman, Khadijeh ^{[1
,2
]}

Karami, Jafar ^{[1
,3
]}

Zarei, Zeinab ^{[4
]}

Hosseinzadeh, Aysooda ^{[2
]}

Kazemi, Mohammad Hossein ^{[5
,6
]}

Moradi-Kalbolandi, Shima ^{[2
]}

Safari, Elahe ^{[1
,7
]}

Farahmand, Leila ^{[2
]}

机构：

[1] Iran Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[2] ACECR, Motamed Canc Inst, Recombinant Prot Dept, Breast Canc Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Rheumatol Res Ctr, Tehran, Iran

[4] ACECR, Motamed Canc Inst, Dept Biomat & Tissue Engn, Breast Canc Res Ctr, Tehran, Iran

[5] Iran Univ Med Sci, Sch Med, Dept Immunol, Student Res Comm, Tehran, Iran

[6] ACECR, Motamed Canc Inst, ATMP Dept, Breast Canc Res Ctr, Tehran, Iran

[7] Iran Univ Med Sci, Immunol Res Ctr, Tehran, Iran

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2020年 / 84卷

关键词：

Breast cancer; Treatment; Nanoparticles; Antibody-drug conjugation systems; Breast cancer stem cells; Immunotherapy; MESENCHYMAL STEM-CELLS; ESTROGEN-RECEPTOR; METRONOMIC CHEMOTHERAPY; PROGESTERONE-RECEPTOR; CLINICAL UTILITY; PROGNOSTIC-FACTORS; THERAPY; RESISTANCE; SURVIVAL; IMMUNOTHERAPY;

D O I：

10.1016/j.intimp.2020.106535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the past recent years, various therapies emerged in the era of breast cancer. Breast cancer is a heterogeneous disease in which genetic and environmental factors are involved. Breast cancer stem cells (BCSCs) are the main player in the aggressiveness of different tumors and also, these cells are the main challenge in cancer treatment. Moreover, the major obstacle to achieve an effective treatment is resistance to therapies. There are various types of treatment for breast cancer (BC) patients. Therefore, in this review, we present the current treatments, novel approaches such as antibody-drug conjugation systems (ADCs), nanoparticles (albumin-, metal-, lipid-, polymer-, micelle-based nanoparticles), and BCSCs-based therapies. Furthermore, prognostic and predictive biomarkers will be discussed also biomarkers that have been applied by some tests such as Oncotype DX, Mamm aPrint, and uPA/PAI-1 are regarded as suitable prognostic and predictive factors in breast cancer.

引用

页数：10

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