Synthesis and 2D QSAR of O-sulphonated β-aminols derivatives as novel antifungal and antibacterial agents

被引：5

作者：

Sharma, Sugandha ^{[1
]}

Pandey, Atindra K. ^{[2
]}

Shukla, Praveen K. ^{[2
]}

Saxena, Anil K. ^{[1
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Fermentat Technol Div, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 21期

关键词：

O-sulphonated beta-aminols; Antifungal; Antibacterial; QSAR; EPIDEMIOLOGY; INFECTIONS; EPOXIDES; AMINES;

D O I：

10.1016/j.bmcl.2011.08.078

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of a series of beta-aminol derivatives using regioselective opening reaction catalyzed by SiO2 (60-120 mesh) and O-sulphonation in THF-KOH system, comprising tert-butoxycarbonyl at secondary nitrogen and evaluate for various stains of bacteria and fungi. SAR study of synthesized compound using backward regression analysis. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：6476 / 6481

页数：6

共 29 条

[1]

[Anonymous], 2008, FACT SHEET 310

[2]

[Anonymous], 2002, P NAT COMM CLIN LAB

[3]

Arendrup M. C., 2005, J CLIN MICROBIOL, V4434, P43

[4] The millennium bugs - the need for and development of new antibacterials [J].

Bax, R ;

Mullan, N ;

Verhoef, J .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (01) :51-59

[5] Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance [J].

Cassell, GH ;

Mekalanos, J .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (05) :601-605

[6] An efficient synthesis of 2-amino alcohols by silica gel catalysed opening of epoxide rings by amines [J].

Chakraborti, AK ;

Rudrawar, S ;

Kondaskar, A .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (09) :1277-1280

[7] RIMOCIDIN .1. CARBON SKELETON PARTIAL STRUCTURE AND ABSOLUTE CONFIGURATION AT C-27 [J].

COPE, AC ;

BURROWS, EP ;

DERIEG, ME ;

MOON, S ;

WIRTH, WD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (23) :5452-&

[8] BETA-ADRENERGIC BLOCKING AGENTS .2. PROPRANOLOL AND RELATED 3-AMINO-I-NAPHTHOXY-2-PROPANOLS [J].

CROWTHER, AF ;

SMITH, LH .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (05) :1009-+

[9]

Daicel Chemical Industries Ltd, 1994, European Patent Application, Patent No. [0 654 534 A2, 0654534]

[10] Invasive fungal infections: a review of epidemiology and management options [J].

Enoch, D. A. ;

Ludlam, H. A. ;

Brown, N. M. .

JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 55 (07) :809-818

← 1 2 3 →