MCM proteins: DNA damage, mutagenesis and repair

被引：105

作者：

Bailis, JM ^{[1
]}

Forsburg, SL ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Mol & Cell Biol Lab, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.gde.2003.11.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The IMCM2-7 complex, which may act as a replicative helicase during DNA synthesis, plays a central role in S-phase genome stability. MCM proteins are required for processive DNA replication and are a target of S-phase checkpoints. Loss of MCM function causes DNA damage and genome instability. MCM expression is upregulated in proliferating cells, providing a diagnostic marker for both cancerous cells and cells with the potential to become malignant. The role of the MCM complex in genome integrity reflects its activity both at active replication forks and away from forks.

引用

页码：17 / 21

页数：5

共 69 条

[1] Components and dynamics of DNA replication complexes in S-cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase [J].

Aparicio, OM ;

Weinstein, DM ;

Bell, SP .

CELL, 1997, 91 (01) :59-69

[2]

BAILLIS JM, 2003, IN PRESS NAT CELL BI

[3] DNA replication in eukaryotic cells [J].

Bell, SP ;

Dutta, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :333-374

[4] Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair [J].

Bird, AW ;

Yu, DY ;

Pray-Grant, MG ;

Qiu, QF ;

Harmon, KE ;

Megee, PC ;

Grant, PA ;

Smith, MM ;

Christman, MF .

NATURE, 2002, 419 (6905) :411-415

[5] Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1 [J].

Burke, TW ;

Cook, JG ;

Asano, M ;

Nevins, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (18) :15397-15408

[6] ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones [J].

Cha, RS ;

Kleckner, N .

SCIENCE, 2002, 297 (5581) :602-606

[7] Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants [J].

Chen, C ;

Kolodner, RD .

NATURE GENETICS, 1999, 23 (01) :81-85

[8] Drosophila Mcm10 interacts with members of the prereplication complex and is required for proper chromosome condensation [J].

Christensen, TW ;

Tye, BK .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (06) :2206-2215

[9] Visualization of replication initiation and elongation in Drosophila [J].

Claycomb, JM ;

MacAlpine, DM ;

Evans, JG ;

Bell, SP ;

Orr-Weaver, TL .

JOURNAL OF CELL BIOLOGY, 2002, 159 (02) :225-236

[10] DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1 [J].

Cobb, JA ;

Bjergbaek, L ;

Shimada, K ;

Frei, C ;

Gasser, SM .

EMBO JOURNAL, 2003, 22 (16) :4325-4336

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