Peritoneal cancer index predicts severe complications after ovarian cancer surgery

被引:13
作者
Lomnytska, Marta [1 ,2 ]
Karlsson, Evelina [1 ,3 ]
Jonsdottir, Bjorg [1 ,2 ]
Lejon, Ann-Marie [2 ]
Stalberg, Karin [1 ,2 ]
Poromaa, Inger Sundstrom [1 ,2 ]
Silins, Ilvars [2 ,4 ]
Graf, Wilhelm [4 ]
机构
[1] Uppsala Univ, Dept Womens & Childrens Hlth, S-75185 Uppsala, Sweden
[2] Uppsala Univ Hosp, Dept Obstet & Gynecol, S-75185 Uppsala, Sweden
[3] Gavleborg Reg Hosp, Dept Obstet & Gynecol, S-80188 Gavle, Sweden
[4] Uppsala Univ, Dept Surg Sci, S-75185 Uppsala, Sweden
来源
EJSO | 2021年 / 47卷 / 11期
关键词
Ovarian cancer; Peritoneal cancer index; Postoperative complications; Cytoreduction score; Overall survival; PRIMARY DEBULKING SURGERY; HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; SEVERE POSTOPERATIVE COMPLICATIONS; ABDOMINAL-WALL METASTASES; ADVANCED-STAGE OVARIAN; NEOADJUVANT CHEMOTHERAPY; CYTOREDUCTIVE SURGERY; MAJOR COMPLICATIONS; BOWEL RESECTIONS; PROGNOSTIC VALUE;
D O I
10.1016/j.ejso.2021.05.019
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: prediction and importance of severe postoperative complications after ovarian cancer surgery is a strong issue in patient selection and evaluation. Pre-and early peroperative predictors of severe 30-days postoperative complications (Clavien-Dindo class >3) after surgery for primary ovarian cancer are not fully established, neither their impact on patients' survival. Materials and methods: A prospective observational study included 256 patients with primary ovarian cancer FIGO stages IIB-IV, operated during 2009-2018 in a primary or interval debulking surgery setting. Patient variables were analysed in relation to severe postoperative complications (Clavien-Dindo class >3) and overall survival. Results: High-grade postoperative complications occurred in 24.2% patients. Class 3a complications were observed in 12.5% cases. High-grade complications class >3 were observed in 31.6% after primary debulking surgery compared to 12.2% after interval debulking surgery (p = 0.0004). Peritoneal cancer index >21 and preoperative albumin concentration <33 g/L were independent predictors of high-grade complications. Peritoneal cancer index correlated with the surgical complexity score and completeness of cytoreduction. Increased peritoneal cancer index was a negative predictor of overall survival, but highgrade complications did not influence survival negatively. Conclusions: Peritoneal cancer index >21 was an independent predictor of high-grade complications after ovarian cancer surgery. Increased peritoneal cancer index also impacted overall survival negatively, but high-grade complications did not influence overall survival. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:2915 / 2924
页数:10
相关论文
共 43 条
  • [1] Relationship among surgical complexity, short-term morbidity, and overall survival in primary surgery for advanced ovarian cancer
    Aletti, Giovanni D.
    Dowdy, Sean C.
    Podratz, Karl C.
    Cliby, William A.
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2007, 197 (06) : 676.e1 - 676.e7
  • [2] Multidisciplinary approach in the management of advanced ovarian cancer patients: A personalized approach. Results from a specialized ovarian cancer unit
    Aletti, Giovanni Damiano
    Garbi, Annalisa
    Messori, Pietro
    Achilarre, Maria Teresa
    Zanagnolo, Vanna
    Rizzo, Stefania
    Alessi, Sarah
    Bocciolone, Luca
    Landoni, Fabio
    Biffi, Roberto
    Carinelli, Silvestro
    Colombo, Nicoletta
    Maggioni, Angelo
    [J]. GYNECOLOGIC ONCOLOGY, 2017, 144 (03) : 468 - 473
  • [3] Impact of Abdominal Wall Metastases on Prognosis in Epithelial Ovarian Cancer
    Ataseven, Beyhan
    du Bois, Andreas
    Harter, Philipp
    Prader, Sonia
    Grimm, Christoph
    Kurzeder, Christian
    Schneider, Stephanie
    Heikaus, Sebastian
    Kahl, Anett
    Traut, Alexander
    Heitz, Florian
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2016, 26 (09) : 1594 - 1600
  • [4] Prognostic impact of debulking surgery and residual tumor in patients with epithelial ovarian cancer FIGO stage IV
    Ataseven, Beyhan
    Grimm, Christoph
    Harter, Philipp
    Heitz, Florian
    Traut, Alexander
    Prader, Sonia
    du Bois, Andreas
    [J]. GYNECOLOGIC ONCOLOGY, 2016, 140 (02) : 215 - 220
  • [5] Postoperative Complications After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Affect Long-term Outcome of Patients With Peritoneal Metastases From Colorectal Cancer: a Two-Center Study of 101 Patients
    Baratti, D.
    Kusamura, S.
    Iusco, D.
    Bonomi, S.
    Grassi, A.
    Virzi, S.
    Leo, E.
    Deraco, M.
    [J]. DISEASES OF THE COLON & RECTUM, 2014, 57 (07) : 858 - 868
  • [6] Association of Preoperative Thrombocytosis and Leukocytosis With Postoperative Morbidity and Mortality Among Patients With Ovarian Cancer
    Barber, Emma L.
    Boggess, John F.
    Van Le, Linda
    Kim, Kenneth H.
    Bae-Jump, Victoria L.
    Brewster, Wendy R.
    Soper, John T.
    Gehrig, Paola A.
    [J]. OBSTETRICS AND GYNECOLOGY, 2015, 126 (06) : 1191 - 1197
  • [7] An analysis of patients with bulky advanced stage ovarian, tubal, and peritoneal carcinoma treated with primary debulking surgery (PDS) during an identical time period as the randomized EORTC-NCIC trial of PDS vs neoadjuvant chemotherapy (NACT)
    Chi, Dennis S.
    Musa, Fernanda
    Dao, Fanny
    Zivanovic, Oliver
    Sonoda, Yukio
    Leitao, Mario M.
    Levine, Douglas A.
    Gardner, Ginger J.
    Abu-Rustum, Nadeem R.
    Barakat, Richard R.
    [J]. GYNECOLOGIC ONCOLOGY, 2012, 124 (01) : 10 - 14
  • [8] The incidence of major complications after the performance of extensive upper abdominal surgical procedures during primary cytoreduction of advanced ovarian, tubal, and peritoneal carcinomas
    Chi, Dennis S.
    Zivanovic, Oliver
    Levinson, Kimberly L.
    Kolev, Valentin
    Huh, Jae
    Dottino, Joseph
    Gardner, Ginger J.
    Leitao, Mario M., Jr.
    Levine, Douglas A.
    Sonoda, Yukio
    Abu-Rustum, Nadeem R.
    Brown, Carol L.
    Barakat, Richard R.
    [J]. GYNECOLOGIC ONCOLOGY, 2010, 119 (01) : 38 - 42
  • [9] Trends in Mortality After Primary Cytoreductive Surgery for Ovarian Cancer: A Systematic Review and Metaregression of Randomized Clinical Trials and Observational Studies
    Di Donato, Violante
    Kontopantelis, Evangelos
    Aletti, Giovanni
    Casorelli, Assunta
    Piacenti, Ilaria
    Bogani, Giorgio
    Lecce, Francesca
    Panici, Pierluigi Benedetti
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2017, 24 (06) : 1688 - 1697
  • [10] Classification of surgical complications - A new proposal with evaluation in a cohort of 6336 patients and results of a survey
    Dindo, D
    Demartines, N
    Clavien, PA
    [J]. ANNALS OF SURGERY, 2004, 240 (02) : 205 - 213