A Dual-Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy

被引：325

作者：

Wang, Hongyu ^{[1
]}

Chang, Jinjie ^{[1
]}

Shi, Mingwan ^{[1
]}

Pan, Wei ^{[1
]}

Li, Na ^{[1
]}

Tang, Bo ^{[1
]}

机构：

[1] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Key Lab Mol & Nano Probes,Minist Educ,Inst Mol &, Jinan 250014, Shandong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

antitumor agents; cancer treatment; drug delivery; organic photothermal agents; photothermal therapy; CANCER-CELL DEATH; HYPERTHERMIA; DELIVERY;

D O I：

10.1002/anie.201811273

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual-targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual-targeted photothermal agent.

引用

页码：1057 / 1061

页数：5

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