A novel allele, HLA-G*010114, with a non-coding DNA base change in exon 2

被引：6

作者：

Arnaiz-Villena, A. ^{[1
]}

Serrano-Vela, J. I. ^{[1
]}

Reguera, R. ^{[1
]}

Perez-Saborido, B. ^{[2
]}

Moreno, E. ^{[2
]}

Moscoso, J. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Dept Immunol, Madrid Reg Blood Ctr, E-28040 Madrid, Spain

[2] Hosp 12 Octubre, Dept Liver & Gastrointestinal Surg, E-28041 Madrid, Spain

来源：

TISSUE ANTIGENS | 2008年 / 71卷 / 03期

关键词：

autoimmunity; foetus; human leucocyte antigen-G; natural killer cells; tolerance; transplantation;

D O I：

10.1111/j.1399-0039.2007.01000.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The non-classical human leucocyte antigen (HLA) class I locus, HLA-G, shows a low protein polymorphism and a more varied DNA (eight proteins and 28 alleles). HLA-G DNA polymorphism accounts mainly for changes at third codon bases of the protein coding exons; this does not imply amino acid change in most cases. This relatively high HLA-G DNA polymorphism in comparison with their protein polymorphism suggests that evolutionary forces are acting upon HLA-G for invariance. This may be related to the immunotolerogenic function postulated for HLA-G.

引用

页码：258 / 259

页数：2

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