Hematopoietic Stem Cells and Regeneration

被引：7
作者：
Biermann, Mitch [1 ]
Reya, Tannishtha [1 ,2 ]
机构：
[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2022年 / 14卷 / 08期
关键词：
ACUTE MYELOID-LEUKEMIA; COLONY-FORMING CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; REGULATES SELF-RENEWAL; IN-VIVO GENERATION; PROGENITOR CELLS; DNA-DAMAGE; HIGH-RISK;
D O I：
10.1101/cshperspect.a040774
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Hematopoietic stem cell (HSC) regeneration is the remarkable process by which extremely rare, normally inactive cells of the bone marrow can replace an entire organ if called to do so by injury or harnessed by transplantation. HSC research is arguably the first quantitative single-cell science and the foundation of adult stem cell biology. Bone marrow transplant is the oldest and most refined technique of regenerative medicine. Here we review the intertwined history of the discovery of HSCs and bone marrow transplant, the molecular and cellular mechanisms of HSC self-renewal, and the use of HSCs and their derivatives for cell therapy.
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页数：21
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